- Assistant Professor, Microbiology
UW Medicine South Lake Union
750 Republican St
Office: F-840
Seattle, WA 98109
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Patrick is a proud alumnus of Pitzer College. He received his Ph.D. from the University of Washington and the Fred Hutchinson Cancer Research Center under the mentorship of Dr. Harmit Malik and Dr. Michael Emerman studying the evolution of host-virus interactions. Patrick completed his postdoctoral training with Russell Vance at the University of California, Berkeley, where he studied pathogen (both viral and bacterial) detection by a class of host innate immune sensors called inflammasomes.
Research in the Mitchell lab is focused on understanding basic principles that govern host-pathogen interactions that influence host immunity and pathogenesis. We are particularly interested in molecular innovations born from host-pathogen evolutionary ‘arms races.’ We combine approaches from evolution, genetics, biochemistry, immunology and microbiology to decipher mechanisms that govern innate immune recognition and other host-pathogen interactions.
- PhD (University of Washington)
- Diverse viral proteases activate the NLRP1 inflammasome.Tsu BV, Beierschmitt C, Ryan AP, Agarwal R, Mitchell PS, Daugherty MDeLife. 2021 01; 10 :
- NAIP-NLRC4-deficient mice are susceptible to shigellosis.Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance REeLife. 2020 10; 9 :
- Molecular characterization of a fungal gasdermin-like protein.Daskalov A, Mitchell PS, Sandstrom A, Vance RE, Glass NLProceedings of the National Academy of Sciences of the United States of America. 2020 08; 117 31: 18600-18607
- Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant.Herlin T, Jørgensen SE, Høst C, Mitchell PS, Christensen MH, Laustsen M, Larsen DA, Schmidt FI, Christiansen M, Mogensen THRheumatology (Oxford, England). 2020 09; 59 9: 2334-2339
- The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.Mitchell PS, Sandstrom A, Vance RECurrent opinion in immunology. 2019 10; 60 : 37-45