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Pre-Exposure Prophylaxis (PrEP) and Protective Immune Responses Against HIV-1

This project will explore anti-HIV-1 responses in HIV-1-exposed but uninfected persons receiving PrEP, evaluate the relationship between anti-HIV-1 immune responses and protection against HIV-1 acquisition and control of viral replication in breakthrough infections observed during prospective follow-up, and, in an exploratory study, collect and test mucosal samples from persons on PrEP to evaluate immune responses at the site of HIV-1 exposure. Funding is provided through an NIH R01 award to Dr. Lund and Baeten.

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