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WHO-Recommended Periodic Presumptive Treatment versus Doxycycline Post-Exposure Prophylaxis for STI Control among Cisgender Men Who Have Sex with Men in Kenya

The objective is to conduct a randomized clinical trial comparing WHO-recommended periodic presumptive treatment (PPT) or doxycycline post-exposure prophylaxis (doxyPEP), compared to standard syndromic treatment. The study will enroll 2900 gay and bisexual men and other men who have sex with men at sites in Kisumu, Nairobi, and Mombasa, Kenya.

This work will provide critical data needed to inform guidelines and improve STI control among MSM in sub-Saharan Africa and other resource-limited settings, including modelled estimates of the health and economic impact of scaling up these two interventions on STI control among MSM and their partners in Kenya.

DGH collaborators include Monisha Sharma and S.O. Soge, and other UW collaborators are Scott McClelland in Medicine, Deven Hamilton at the CSDE, and Steven Goodreau in Anthroplogy. Partners include Kenyan site PIs Dr. Fredrick Otieno with Nyanza Reproductive Health Society in Kisumu and Dr. Joshua Kimani with Partners for Health & Development in Africa, and grant MPI Dr. Eduard Sanders with the Aurum Institute.