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The effect of HIV exposure and infection on immunity to TB in children

The proposed study aims to determine the effect of HIV exposure on trained immunity in BCG-vaccinated infants (Aim 1), test the hypothesis that maternal HIV exposure and infant HIV infection modifies anti-mycobacterial immunity via epigenetic reprogramming of innate immune cells (Aim 2), and determine prevalence, predictors, and effect (on TB infection and disease) of anti-mycobacterial immunity in HIV+ children (Aim 3).

Active Dates 
01/01/2019 to 12/31/2023
Health Topics