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Identification of Novel Mucosal Immune Mechanisms Involved in Protection from HIV-1

As the HIV-1 epidemic continues to spread, the development of a prophylactic vaccine remains a high-priority challenge. A barrier to the effective design of an HIV-1 vaccine is the lack of known natural correlates of protection from infection. We propose to use mucosal sampling of a novel cohort including male and female HIV-1-exposed seronegative men and women, combined with state-of-the-art immunological techniques, to identify novel mucosal immune mechanisms of protection from HIV-1 infection.