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Using single cell systems biology to evaluate the role of prior infection in vaccine-induced protection

The goal of this proposal is to elucidate why several promising experimental vaccines have failed to achieve efficacy in the field after they demonstrated high levels of protection in human clinical trials involving pathogen-naïve individuals, despite inducing similar immune responses. We will use a suite of single cell biology approaches to elucidate how changes in the induction of humoral immunity and host-parasite interactions are altered in the presence of pre-existing humoral immunity to malaria infection and then evaluate the impact of these changes on vaccine efficacy.

Active Dates 
07/01/2018 to 06/30/2020
Faculty Involved