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Health Topics 123

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Resistance to M. tuberculosis

In endemic settings, some adults who are heavily and repeatedly exposed to M. tuberculosis never develop latent tuberculosis infection (LTBI) as defined by a positive tuberculin skin test (TST) or interferon gamma release assay (IGRA). These individuals, may "resist" M.tb infection.  We are part of an international consortium that is trying to understand the immune mechanisms underlying this clinical phenotype.  Our hope is that we will discover the immune mechanisms that are required for protective immunity to M.tb in humans.  This information can then be used to develop new therapies, including vaccines. 

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