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Unconventional T cells and TB

​Peptide antigens are typically presented to T cells by highly polymorphic major histocompatibility complex (MHC) Class I and Class II molecules and have been studied extensively in humans and animal models of tuberculosis.  However, some T cells can also be activated by non-peptide antigens via MHC-independent antigen presenting systems. The role that these "unconventional" T cells play in the pathogenesis of human tuberculosis is a major focus of the lab.

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