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Air Pollution, the social environment and Alzheimer's disease

The purpose of this study is to evaluate the association between air pollution and the social environment on Alzheimer’s disease (AD) in a well characterized cohort of older adults age 75 and older evaluated for dementia between the years 2000-2008. Specifically, we are investigating the impact of air pollutant exposures and the neighborhood social environment  (1) incident AD and cognitive decline, (2) the progression to AD and cognitive trajectories in participants with mild cognitive impairment at study entry, and (3) amyloid-β deposition, which was ascertained in a subset of study participants. We will investigate cardiovascular disease and depression as potential mediators of the effects of air pollutants on AD risk.

Active Dates 
09/15/2017 to 06/30/2022