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Role of Proviral Loci in HIV Latency

HIV persists for many years during therapy and normally rebounds to pretreatment levels when therapy is stopped. However, a small number of individuals have been able to control their infection, despite the presence of infectious virus, for many years after stopping therapy. Understanding the factors that lead to virus control under these circumstances is critical to our ability to achieve this end in others as well as for an eventual cure of infection. We are learning that where the virus integrates its genome into the infected cell genome is of significance to the maintenance of HIV reservoirs. We propose to understand the role HIV has, as it exists at different sites in the infected cell genome, to the persistence of HIV reservoirs in different cell types and tissues, and the ability to control HIV infection after interruption of ART.

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Active Dates 
04/01/2016 to 03/31/2021
Faculty Involved