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Cytomegalovirus (CMV) viremia and mortality in HIV-infected hospitalized children

African children diagnosed with HIV infection late in disease have a mortality rate often exceeding 20%, and there is an urgent need for novel strategies to improve their prognosis. Cytomegalovirus (CMV) infection, and plasma CMV viral load are risk factors for accelerated HIV progression. Additionally, CMV reactivation occurs in up to a third of critically ill non-immunosuppressed patients, and is associated with mortality. This study will focus on CMV viremia in a cohort of children diagnosed with HIV infection while critically ill with aims to determine the impact of CMV viremia on mortality and duration of hospitalization (Aim 1), response to antiretroviral therapy initiation (Aim 2), and Immune activation and inflammation (Aim 3).

Active Dates 
09/01/2018 to 08/31/2020
Faculty Involved 
Health Topics