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Identification of drug-targetable IFN-stimulated genes mediating immune activation during ART-treated HIV-1 infection.

The objective of this proposal is to evaluate changes in IFN stimulated gene expression patterns following ART initiation among HIV-1 infected individuals and determine how those changes are association with viral and immunologic parameters. Additionally, the proposed research will use bioinformatics approaches to identify existing drugs with potential to be re-purposed for treating chronic immune activation during HIV-1 infection. 

Active Dates 
06/05/2018 to 05/31/2023
Faculty Involved 
Health Topics