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A phase 1 clinical trial to evaluate the safety and immunogenicity of HIV clade C DNA and of MF59-adjuvant clade C Env protein, in heathy, HIV-uninfected adult participants (HVTN 111)

HVTN 111 forms part of the Correlates Programme which will be evaluating several different vaccine regimens containing combinations of next-generation vaccine products as well as different adjuvant systems. The study is using 2 different vaccines: the DNA-HIV-PT123 and Bivalent Subtype C gp120/MF59.  In addition, HVTN 111 is investigating 2 different delivery systems for the DNA vaccine i.e. delivery of DNA vaccine via Biojector versus needle and syringe.  Based on safety and immunogenicity data collected, this study has the potential to advance to a phase 2b proof-of-concept efficacy trial. Funding is provided by HIV Vaccine Trials Network. 

Active Dates 
06/01/2016 to 07/31/2017