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HIV integration-mediated modulation of immune regulation in HPV-associated cancers

This project will compare cervical tissues from HIV-infected women who have progressed to pre-cancer/carcinoma to those with spontaneous clearance of high-risk HPV infections to determine if tissues differ in distribution of HIV integration sites, density of T regulatory cells with HIV proviruses and expression of checkpoint molecules, and immune protein profiles in cervical secretions. The major goals of this project are to determine whether HIV infection drives a novel mechanism for HPV-associated cancer development and progression.

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Active Dates 
09/01/2016 to 08/31/2021
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