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Immunoprotective Properties of Tissue-resident Memory T Cells in Mice and Humans within Mucosal Sites

The goal of this project is to thoroughly define the immunoprotective role of tissue resident T cells (TRM) against viral pathogens. Underlying the proposed experiments is the idea that TRM have the ability to rapidly contain viruses within microscopic tissue microenvironments over rapid timeframes. Therefore, the proposed research project will focus on critical features of TRM such as gene expression profile, homeostasis, apoptosis and trafficking, before, during and at multiple time points following clearance of a mucosal virus within microscopic sites of infection.

Active Dates 
07/01/2016 to 06/30/2021
Faculty Involved