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Faculty 433
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Optimizing HIV immunogen-BCR interactions for vaccine development

This grant aims at understanding the relation between the binding affinity of Env-based immunogens with B cell receptors (BCRs) on the surface of B cells and the subsequent fate of these B cells (i.e., proliferation, anergy, or apoptosis). The ultimate goal is to define whether a range of Env-BCR binding affinities exists or not for optimal Env-based B cell stimulation. 

Countries 
Active Dates 
05/01/2011 to 04/30/2018
Faculty Involved 
Health Topics