Discover our impact all over the world.

Numbers displayed on the map are a representation of the activity in each country. Once you use the filter selections below, you will have the opportunity to explore projects and faculty in each country.

Projects + Faculty = Activity Number

##

Overview

Projects 716
Countries 135
Faculty 405
Health Topics 136

Filter from the selections below

Clear All Filters

Base J and transcription termination in Leishmania

The major goal of this project is to critically assess the hypothesis that the modified DNA base J serves as a critical signal for transcription termination, and that loss of proper termination in J-deficient cells kills the parasite. The proposed studies will increase our understanding of the role of J in controlling transcription in these organisms, and may provide insight into a possible role for similar base modifications in other eukaryotes. Furthermore, since base J is not found in the mammalian hosts of Leishmania (including humans), this information will provide a new opportunity for the development of novel chemotherapeutic agents against these important parasites.

Countries 
Active Dates 
06/11/2013 to 05/31/2018
Faculty Involved