Perturbations of host cell signaling by a complex hepatotropic pathogen

This NIH funded project focuses on signaling in hepatocytes after infection with a complex pathogen. Our primary aim is to better understand the molecular events that render the infected hepatocyte impermeable to apoptosis induced by intracellular Plasmodium species. This work will inform the fundamental understanding of the interaction between this extremely relevant eukaryotic pathogen and its hepatocyte host.