- Adjunct Assistant Professor, Global Health
- Assistant Professor, Pediatrics - Infectious Diseases
307 Westlake Ave N
Seattle, WA 98109
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The Harrington Lab focuses on intergenerational immune interactions and their effect on susceptibility to infection during pregnancy and infection. In particular, we investigate the role of maternal microchimerism (maternal cells acquired by the fetus in utero) in fetal and infant immune development, early vaccine responses, and susceptibility to infection including malaria, HIV, pneumonia, and diarrhea. We have ongoing collaborations with Drs. Lisa Frenkel and Heather Jaspan from Seattle Children’s, Dr. Marion Pepper from the University of Washington, and Dr. Lee Nelson from the Fred Hutchinson Cancer Research Center.
- Infectious Diseases
- Maternal Child Health (incl. Reproductive Health)
- Molecular Immunology
Kanaan SB, Gammill HS, Harrington WE, De Rosa SC, Stevenson PA, Forsyth AM, Allen J, Cousin E, van Besien K, Delaney CS and Nelson JL. Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant. Oncoimmunology 2017 6(5):e1311436. PMID28638735. PMC5467984.
Harrington WE, Kanaan SB, Muehlenbachs A, Morrison R, Stevenson P, Fried M, Duffy PE and Lee Nelson J. Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood. J Infect Dis 2017 May 1;215(9):1445-1451. PMID28329160. PMC5790147.
Gammill HS and Harrington WE. Microchimerism: Defining and redefining the prepregnancy context - A review. Placenta 2017 Dec;60:130-133. Review. PMID28911790. PMC5718967.
Harrington WE, Kakuru A and Jagannathan P. Malaria in pregnancy shapes the development of fetal and infant immunity. Parasite Immunol 2018 Jul 17:e12573. PMID30019470. Review.
Shree R, Harrington WE, Kanaan SB, Forsyth A, Cousin E, Lopez A, Nelson JL and Gammill HS. Fetal microchimerism by mode of delivery: a prospective cohort study. BJOG 2019 Jan;126(1):24-31. PMID30102819. PMC6294652.