- Adjunct Professor, Global Health
- Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Professor, Laboratory Medicine and Pathology
Division of Allergy and Infectious Diseases
Box 358061, Room E683
750 Republican St
Seattle, WA 98195
Select from the following:
Tom’s laboratory examines why individuals have different susceptibility to infections and whether these insights can lead to novel treatment and vaccine strategies. Studies include examining the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections. His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.
- MD (Johns Hopkins University)
- PhD (Johns Hopkins University)
- AB (Princeton University)
Simmons JD, Peterson GJ, Campo M, Lohmiller J, Skerrett SJ, Tunaru S, Offermanns S, Sherman DR, Hawn TR. Nicotinamide Limits Replication of Mycobacterium tuberculosis and Bacille Calmette-Guérin Within Macrophages. J Infect Dis. 2020 Mar 2;221(6):989-999.
Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol. 2018 Sep; 18(9):575-589.
Shah, JA, Musvosi, M, Shey, M, Horne, DJ, Wells, RD, Peterson, GJ, Cox, JS, Daya, M, Hoal, EG, Lin, L, Gottardo, R, Hanekom, WA, Scriba, TJ, Hatherill, M, Hawn TR. A functional TOLLIP variant is associated with BCG-specific immune responses and tuberculosis. Amer. J. Resp. Care and Critical Medicine. 2017; 96:502-511.
Randhawa, AK, Shey, MS, Keyser, A, Peixoto, B, Wells, RD, de Kock, M, Lerumo, L, Hughes, J, Hussey, G, Hawkridge, A, Kaplan, G, Hanekom, WA, Hawn TR, and the SATVI team. Association of Human TLR1 & TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants. PLoS Pathogens. 2011; 7:e1002174.
Thuong, NTT, Dunstan, SJ, Chau, TTH, Thorsson, V, Simmons, SP, Quyen, NTH, Thwaites, GE, Lan, NTN, Hibberd, M, Teo, YY, Seielstad, M, Aderem, A, Farrar, JJ and Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathogens. 2008; 4:e1000229.
Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR (2018) Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol [Epub ahead of print]. PMID 29895826.
Lu LL, Smith MT, Yu KKQ, Luedemann C, Suscovich TJ, Grace PS, Cain A, Yu WH, McKitrick TR, Lauffenburger D, Cummings RD, Mayanja-Kizza H, Hawn TR, Boom WH, Stein CM, Fortune SM, Seshadri C, Alter G. IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure. Nature Medicine. 2019. May20. PMID 31110348