- Affiliate Professor, Global Health
- Vice President, Drug Discovery, IDRI
Infectious Disease Research Institute
1616 Eastlake Avenue E
Seattle, WA 98102
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Tanya Parish is the Senior Vice President of Drug Discovery at IDRI where she heads the TB Discovery Research group. Her work focuses on the discovery of new drugs that are effective at curing drug-sensitive and drug-resistant tuberculosis with the added goal of shortening the time it takes to cure disease. This encompasses a range of early stage drug discovery including drug target identification and validation, high throughput screening and medicinal chemistry. In addition, her group works to understand the pathogenic mechanisms and basic biology of the global pathogen Mycobacterium tuberculosis and using this information to inform drug discovery.
- PhD (National Institute For Med Res (UK))
- BSc (University of London (UK))
- Drug and Vaccine Development
- Infectious Diseases
- Infectious Diseases (other than STDs)
The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents. 2017. E. Zuniga, A. Korkegian, S. Mulle, E.J. Hembre, P.L. Ornstein, G. Cortez, K. Biswas, N. Kumar, J. Cramer, T. Masquelin, P.A. Hipskind, J. Odingo and T. Parish. Bioorg Med Chem. 25:3922-3946. PMID: 28576632
Azoles induce reactive oxygen species in Mycobacterium tuberculosis which is not associated with cell death. 2017. H.A. Howell Wescott, D.M. Roberts, C.L. Allebach, R. Kokoczka and T. Parish. ACS Omega.2: 41-51. PMCID# PMC5286457
A target-based whole cell screen approach to identify inhibitors of Mycobacterium tuberculosis signal peptidase. 2016. S.A. Bonnett, J. Ollinger, S. Chandrasekera, S. Florio, T. O’Malley, M. Files, J. Jee, J. Ahn, A. Casey, Y. Ovechkina, D. Roberts, A. Korkegian, T. Parish. ACS Inf Dis. 2: 893-902. PMID: 27642770. PMCID# PMC5215716.
Mycobacterium tuberculosis H37Rv has a mutation in PhoR which affects cell wall hydrophobicity and gene expression. 2015. L.J. Schreuder, P. Carroll, J. Muwanguzi-Karugaba, R. Kokoczka, A.C. Brown and T. Parish. Microbiology. (Editor’s Choice). 161: 765-773.
A. Korkegian, D.M. Roberts, R. Blair, T. Parish. Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan. J Biol Chem. 2014. 289: 35172-35181.