- Associate Professor, Global Health
- Associate Professor, Allergy and Infectious Dis.
- Adjunct Associate Professor, Epidemiology
325 Ninth Avenue
Seattle, WA 98104
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Dr. Graham earned a medical degree from McGill University in Montreal, Canada, a master's degree in public health from Boston University in Boston, Massachusetts, USA, and a PhD in clinical epidemiology from the University of Toronto in Toronto, Canada. She holds Visiting Scientist appointments at the University of Nairobi and the Kenya Medical Research Institute.
Dr. Graham is currently an Associate Professor of Medicine and Global Health and an Adjunct Associate Professor of Epidemiology. She has been in the UW Department of Medicine since 2003, when she came from Brigham & Women's Hospital to begin fellowship in Infectious Diseases and a career in HIV research. She has authored or co-authored 59 peer-reviewed publications, including 19 first-author and 10 senior-author publications in such journals as the Journal of Infectious Diseases, AIDS, Journal of the Acquired Immunodeficiency Syndrome (JAIDS), and PLoS One. In addition, she directs the UW School of Medicine's Global Health Pathway and is the Track Director for the University of Washington's concurrent MD-MPH program in Global Health. She also directs the annual "Principles of STD/HIV Research" course, with co-director Rachel Winer.
Dr. Graham's major research interests are in two areas: (1) HIV treatment and prevention, with a focus on marginalized populations; and (2) HIV pathogenesis and disease progression. Her work on HIV treatment and prevention is based in Kenya, and focuses on female sex workers (FSW) and men who have sex with men (MSM). She is currently leading an NIH-funded R34 project to develop and test an intervention to promote adherence to antiretroviral therapy among HIV-positive MSM, using provider and peer support. In addition, she is a co-investigator for ongoing cohort studies of MSM and other high-risk adults on the Kenyan coast and for a new study, called "Anza Mapema" to demonstrate the effectiveness of a test and treat approach for MSM in Kisumu, Kenya. She is also studying the impact of sexual violence on physiologic and immunologic biomarkers of HIV risk among FSW in Mombasa, Kenya.
Dr. Graham's work on HIV pathogenesis and disease progression has focused on the role of endothelial activation and hemostasis/thrombosis in the development of non-AIDS defining complications such as all-cause mortality, Kaposi sarcoma, myocardial infarction, chronic obstructive pulmonary disease, and ischemic stroke.
- PhD (University of Toronto (Canada))
- MD (McGill University (Canada))
- MPH (Boston University)
- STDs (other than HIV)
Graham SM, Mugo P, Gichuru E, et al. Adherence to antiretroviral therapy and clinical outcomes among young adults reporting high-risk sexual behavior, including men who have sex with men, in Coastal Kenya. AIDS Behav. 2013; 17(4): 1255-65.
Sanders EJ, Okuku HS, Smith AD, Mwangome M, Wahome E, Fegan G, Peshu N, van der Elst EM, Price MA, McClelland RS, Graham SM. High HIV-1 incidence, correlates of HIV-1 acquisition, and high viral loads following seroconversion among MSM. AIDS. 2013; 27(3): 437-46.
Graham SM, Rajwans N, Jaoko W, Estambale BBA, McClelland RS, Overbaugh J, Liles WC. Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression.AIDS. em>2013;27:1803-1813 (PMID: 23807276, PMCID: PMC3883757).
Graham SM, Jalalian-Lechak Z, Shafi J, et al. Antiretroviral treatment interruptions predict female genital shedding of genotypically resistant HIV-1 RNA. J Acquir Immune Defic Syndr. 2012; 60(5): 511-8.
Graham SM, Masese L, Gitau R, et al. Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment: a prospective cohort study. J Infect Dis. 2010; 202(10): 1538-42.