- Affiliate Professor, Global Health
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Dr. Kappe's research focuses on the biology, pathogenesis, immunology and vaccinology of the obligate intracellular malaria parasites of the genus Plasmodium. Malaria continues be one of the most important infectious diseases with tremendous negative health impact on human populations, particularly children and pregnant women in developing countries. No effective vaccine has been developed yet, despite decades of effort. He is particularly interested in the parasite stages that are transmitted by the mosquito vector and the initial stage of infection in the liver. With his team, they have pioneered functional genomics studies and reverse genetics studies of malaria parasites, thereby laying the foundations for their in-depth biological investigation. They have used this knowledge to develop genetically engineered vaccine strains, which are leading vaccine candidates and are used for vaccinology and immunology studies. Dr. Kappe's team works with rodent malaria models and the most lethal human malaria parasite, Plasmodium falciparum and more recently the most important malaria parasite outside of Africa, Plasmodium vivax
- PhD (University of Notre Dame)
- MS (University of Bonn (Germany))
- Host-Pathogen Interactions
- Molecular Immunology
- Assessing the determinants of durable protective immunity in SARS-CoV-2 infected human subjects
- Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines
- Infection-blocking antibody targets for malaria
- Perturbations of host cell signaling by a complex hepatotropic pathogen
Schäfer C, Dambrauskas N, Reynolds LM, Trakhimets O, Raappana A, Flannery EL, Roobsoong W, Sattabongkot J, Mikolajczak SA, Kappe SHI, Sather DN. (2021) Partial protection against P. Vivax infection diminishes hypnozoite burnd and blood stage relapses. Cell Host Microbe. 2021 Apr 8:S1931-3128(21)00139-6. PMID: 33857426.
8Goswami D, Betz W, Locham NK, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Murphy SC, Vaughan AM, Kappe SHI. (2020) A replication-competent late liver stage-attenuated human malaria parasite. JCI Insight. Jun 2. pii: 135589. PMID: 32484795.
Lindner SE, Swearingen KE, Shears MJ, Walker MP, Vrana EN, Hart KJ, Minns AM, Sinnis P, Moritz RL, Kappe SHI. (2019) Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites. Nat Commun. Oct 31;10(1):4964. PMID: 31673027. PMCID: PMC6823429.
Kaushansky A, Douglass AN, Arang N, Vigdorovich V, Dambrauskas N, Kain HS, Austin LS, Sather DN, Kappe SH. (2015) Malaria parasites target the hepatocyte receptor EphA2 for successful host infection. Science. Nov 27;350(6264):1089-92. PMID: 26612952; PMCID: PMC4783171