• Affiliate Professor, Global Health
  • Vice President, Preclinical Biology, IDRI

Infectious Disease Research Institute
1616 Eastlake Ave East, Suite 400
Seattle, WA 98102
United States

Phone Number: 
206-858-6065
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Biography 

Rhea Coler is the Senior Vice President of Preclinical and Translational Research at IDRI. She is an Affiliate Professor in the Department of Global Health at the University of Washington and VP of Research and Development at PAI Life Sciences Inc. Her research focuses on developing vaccines or immunotherapy for tuberculosis, nontuberculous mycobacteria, leishmaniasis, flaviviruses and schistosomiasis.

Dr. Coler serves on the Global Health Undergraduate Programs Advisory Board, and the Boards of the Washington Global Health Alliance (WGHA) and the ARCS Foundation Seattle Chapter. Her work has been funded by NIH/NIAID, Bill & Melinda Gates Foundation, Paul Allen G. Family Foundation, Medical Research Council, Wellcome Trust, European Commission, and PATH. She has published more than 90 peer-reviewed papers. Dr. Coler began her infectious disease career with field work on malaria control in Tanzania, followed by research on arboviruses, entomology and parasitology at the Caribbean Epidemiology Center (CAREC) in Trinidad, West Indies. She received her BSc from McGill University, MSc from the London School of Hygiene and Tropical Medicine, and PhD from the University of Washington.

Education 
  • PhD (University of Washington)
  • MSc (London School of Hygiene & Tropical Medicine (UK))
  • BSc (McGill University (Canada))
Country Affiliations 
Health Topics 
  • Biodefense Infectious Diseases
  • Burden of Disease
  • Clinical Mentoring
  • Drug and Vaccine Development
  • Education and Training
  • Host-Pathogen Interactions
  • Immunizations
  • Implementation Science
  • Infectious Diseases
  • Influenza
  • Innate Immunity
  • Laboratory Strengthening
  • Leadership and Organizational Development
  • Leishmaniasis
  • Malaria
  • Molecular Immunology
  • Neglected Diseases, Tropical Medicine (incl. Parasites)
  • Pathobiology
  • Pathogenesis
  • Poverty
  • Prevention
  • Pulmonary Diseases and Pneumonia
  • Research
  • Respiratory Disease
  • TB
  • Trop. Med (incl. Parasites)
  • Viruses
  • Waterborne Diseases
  • Zoonotic Diseases and Animal Health
Pathobiology research areas 
Expertise 

Candidate vaccines for tuberculosis, leishmaniasis, malaria, HIV, West Nile virus, anthrax and influenza.

Publications 

Coler RN, Day TA, Ellis R, Piazza FM, Beckmann AM, Vergara J, Rolf T, Lu L, Alter G, Hokey D, Jayashankar L, Walker R, Snowden MA, Evans T, Ginsberg A, Reed SG, Team T-S. The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial. NPJ Vaccines. 2018;3:34. doi: 10.1038/s41541-018-0057-5. PMID: 30210819.

Van Hoeven N, Wiley S, Gage E, Fiore-Gartland A, Granger B, Gray S, Fox C, Clements DE, Parks DE, Winram S, Stinchcomb DT, Reed SG, Coler RN. A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen. NPJ Vaccines. 2018;3:39. doi: 10.1038/s41541-018-0077-1. PMID: 30302281.

Baldwin SL, Larsen SE, Ordway D, Cassell G, Coler RN. The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases. PLoS Negl Trop Dis. 2019;13(2):e0007083. doi: 10.1371/journal.pntd.0007083.PMID: 30763316. PMC6375572.

Baldwin SL, Hsu FC, Van Hoeven N, Gage E, Granger B, Guderian JA, Larsen SE, Lorenzo EC, Haynes L, Reed SG, Coler RN. Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection. Front Immunol. 2018 Feb 19;9:295. doi: 10.3389/fimmu.2018.00295. eCollection 2018. PMID: 29515589.

Bertholet S, Ireton GC, Ordway DJ, Windish HP, Pine SO, Kahn M, Phan T, Orme IM, Vedvick TS, Baldwin SL, Coler RN, Reed SG. A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosis. Science translational medicine. 2010;2(53):53ra74. doi: 10.1126/scitranslmed.3001094. PMID: 20944089.