• Affiliate Professor, Global Health
  • Affiliate Professor, Biomedical Informatics and Medical Education
  • Professor, Center for Infectious Disease Research
Peter Myler

Center for Infectious Disease Research
307 Westlake Ave N, Suite 500
Seattle, WA 98109
United States

Phone Number: 
206-256-7332
Select from the following:
Biography 

Dr. Peter Myler has extensive (over 30 years) experience in parasite molecular biology, genomics and bioinformatics and, more recently, structural biology and drug development. After graduate work on malaria antigen identification, he undertook post-doctoral training in molecular biology; studying antigenic variation in African trypanosomes and Anaplasma. During the last post-doctoral period (at SBRI), Dr. Myler has began to study Leishmania gene expression and developed expertise in DNA sequencing and bioinformatics. This led to directing the L. major and T. cruzi genome sequencing projects; an interest that continues until the present as consultant for the trypanosomatid genome database (TriTrypDB). For the last 20 years, Dr. Myler has been at the forefront of applying genome-scale systems biology approaches (such as expression profiling and proteomics) to increase our understanding of molecular mechanisms underlying regulation of trypanosomatid gene expression. His laboratory makes extensive use of genome sequencing (using several platforms), ChIP-seq (chromatin immunoprecipitation) RNA-seq (including ribosome profiling) in several trypanosomatid species. About 15 years ago, Dr. Myler became actively involved in structural genomics, leading the Target Selection portion of the Structural Genomics of Pathogenic Protozoa (SGPP) project. He is currently PI and Director of the Seattle Structural Genomics Center for Infectious Disease (SSGCID), which is funded under a contract from NIAID to solve the structure of proteins targets in emerging and re-emerging infectious disease organisms. This has led to his recent involvement in development of new antimicrobial therapeutics using structure-based drug design.

Education 
  • PhD (University of Queensland (Australia))
  • BSc (University of Queensland (Australia))
Country Affiliations 
Languages 
  • French
Health Topics 
  • Biodefense infectious diseases
  • Drug and Vaccine Development
  • Ebola
  • Host-pathogen Interactions
  • Infectious Diseases
  • Infectious Diseases (other than STDs)
  • Leishmaniasis
  • Malaria
  • Neglected Diseases, Tropical Medicine (incl. Parasites)
  • Pathobiology
  • Research
  • Viruses
  • Zoonotic Diseases and Animal Health
Pathobiology research areas 
Expertise 

regulation of gene expression in protozoan parasites

Publications 

Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E*, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, Muller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O'Neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Schafer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D*, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ. (2005) The genome of the kinetoplastid parasite, Leishmania major. Science 309:436-442. PubMed: 16020728 PMC1470643

van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P. (2012) Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell 150:909-21. PubMed: 22939620 PMC3684241

Genest PA, Baugh L, Taipale A, Zhao W, Jan, S, van Luenen H, Korlach J, Clark T, Luong, K, Turner SW, Myler PJ, Borst P. (2015) Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing. Nucleic Acids Res 43:2102-15. PubMed25662217 PMC4344527

Parson M, Ramasamy G, Vasconcelos EJ, Jensen BC, Myler PJ (2015) Advancing Trypanosoma brucei genome annotation througth ribosome profiling and spliced leader mapping. Mol Biochem Parasitol 202:1-10. PubMed:26393539 PMC4644489

Staker BL, Buchko GW, Myler PJ (2015) Recent contributions of structure-based drug design to the development of antibacterial compounds. Curr Opin Microbiol 27:133-8. PubMed:26458180 PMC4659754