- Associate Professor, Global Health
- Associate Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Associate Professor, Epidemiology
Select from the following:
Paul Drain, MD, MPH, is Associate Professor in the Departments of Global Health, Medicine (Infectious Diseases), and Epidemiology at the University of Washington and a practicing Infectious Disease physician at Harborview Medical Center and the University of Washington Medical Center in Seattle. His research group focuses on development, evaluation and implementation of diagnostic testing and clinic-based screening, including novel point-of-care technologies, to improve clinical care and patient-centered outcomes for tuberculosis and HIV in resource-limited settings.
He is Associate Director of the Tuberculosis Research and Training Center at the University of Washington and teaches the “Clinical Global Health and Social Medicine” course for medical students. He research has been supported by several institutes of the National Institutes of Health, the Infectious Disease Society of America, Bill and Melinda Gates Foundation, Harvard Global Health Institute, both the UW’s and Harvard’s Center for AIDS Research, and the AIDS Healthcare Foundation.
He has authored several global health books and received a Faculty Teaching Award from Harvard Medical School.
- MD (University of Washington)
- MPH (University of Washington)
- BA (Miami University (Ohio))
- Host-Pathogen Interactions
- Infectious Diseases
- Infectious Diseases (other than STDs)
- Respiratory Disease
- STDs (other than HIV)
- V-OLA: point of care HIV viral load monitoring and drug resistance testing
- A rapid point-of-care test to improve PrEP adherence
- Advancing point-of-care diagnostics for integrated HIV and TB care in South Africa
- Developing and Evaluating Point-of-Care Antigen and Immunoassays for COVID-19 and Cytokine Release Syndrome among people being screened for SARS-CoV-2 infection in Seattle
- DO ART: Delivery Optimization of ART
- Drug Resistance Genotypic and Phenotypic Correlates of Efavirenz and Dolutegravir based Treatment Outcomes across Non-B HIV-1 subtypes
- Electrokinetic paper diagnostic platform: 15-minute, quantitative nucleic acid amplification for viral pathogens in whole blood
- Enhancing Pediatric Diagnosis of Tuberculosis with FLOW Technology
- First-in-human clinical validation and feasibility of the Salus urine LAM assay for diagnosing active tuberculosis in South Africa
- HIV-specific target capture and quantitative isothermal amplification for acute HIV diagnosis and treatment monitoring
- Point-of-care Urine Monitoring of Adherence (PUMA): Testing a Real-Time Urine Assay of Tenofovir in PrEP
- Predicting PrEP Uptake and Adherence among Adolescent Girls and Young Women in Sub-Saharan Africa: Leveraging Programmatic and Clinical Trials Data
- Prospective Evaluation of Novel Diagnostics for TB in KwaZulu-Natal, South Africa: The PROVE TB Study
- Simplifying HIV Treatment and Monitoring (STREAM2): Point-of-Care Urine Tenofovir Adherence and Viral Load Testing to Improve HIV Outcomes in South Africa
- Standing Tall - A Pilot Randomized Controlled Trial of a Community-Based Intervention to Improve Health Outcomes for Newly Diagnosed HIV-Positive Young Adults in South Africa
- The GAIN (Greater Access and Impact with NAT) Study: Improving HIV Diagnosis, Linkage to Care, and Prevention Services with HIV Point-of-Care Nucleic Acid Tests (NATs)
Drain PK, Hyle EP, Noubary F, Freedberg KA, Wilson D, Bishai WR, Rodriguez W, Bassett IV. Diagnostic point-of-care tests in resource-limited settings. Lancet Infect Dis. 2014;14:239-49 [original work]. doi: 10.1016/S1473-3099(13)70250-0. PMCID: 4016042.
Drain PK, Kubiak RW, Siriprakaisil O, Klinbuayaem V, Quame-Amaglo J, Sukrakanchana PO, Tanasri S, Punyati P, Siriungsi W, Cressey R, Bacchetti P, Okochi H, Baeten JM, Gandhi M, Cressey TR. Urine tenofovir concentrations correlate with plasma and relates to TDF adherence: A Randomized directly-observed pharmacokinetic trial (TARGET Study). Clin Infect Dis. Published online 17 Jul 2019. doi: 10.1093/cid/ciz645.
Gandhi M, Bacchetti P, Spinelli M, Okochi H, Baeten JM, Sirirakaisal O, Klinbuayaem V, Rodrigues WC, Wang G, Vincent M, Cressey TR, Drain PK. Validation of a urine tenofovir immunoassay for adherence monitoring to PrEP and ART and establishing the cutoff for a point-of-care test. J Acquir Immune Defic Syndr. 2019; 81:72-7. PMCID: 6456396.
Drain PK, Dorward J, Violette LR, Quame-Amaglo J, Thomas KK, Samsunder N, Ngobese H, Mlisana K, Moodley P, Donnell D, Barnabas RV, Naidoo K, Abdool Karim SS, Celum C, Garrett N; STREAM Study Team. Point-of-care HIV viral load testing combined with task shifting to improve treatment outcomes (STREAM): findings from an open-label, non-inferiority, randomised controlled trial. Lancet HIV. 2020;7:e229-37 [original work]. doi: 10.1016/S2352-3018(19)30402-3. PMCID: 7183312