- Affiliate Associate Professor, Global Health
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Dr. Sather studies antibody-mediated immunity and vaccine development for HIV-1 and Malaria. His laboratory is interested in understanding how vaccine- or pathogen-specific B cells are triggered, and on defining their natural history along their journey to becoming protective antibody responses. Their goal is to leverage those findings toward the development of novel immunogens and vaccine regimens to elicit protective antibody responses.
- PhD (Wayne State University)
- Drug and Vaccine Development
- Host-Pathogen Interactions
- Infectious Diseases
- Molecular Immunology
- Development of a pre-erythrocytic P. vivax vaccine to prevent clinical relapse
- Harnessing Oral Mucosa Vaccination to Drive Protective HIV Antibody Responses
- Infection-blocking antibody targets for malaria
- Kinetics, evolution, and effector function of Fc repertoires during vaccination with native-like Env trimers
- Using single cell systems biology to evaluate the role of prior infection in vaccine-induced protection
Vijayan K, Visweswaran GRR, Chandrasekaran R, Trakhimets O, Brown SL, Watson A, Zuck M, Dambrauskas N, Raappana A, Carbonetti S, Kelnhofer-Millevolte L, Glennon EKK, Postiglione R, Noah Sather DN*, Kaushansky A*. Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage. Cell Rep [Internet]. Elsevier; 2021 Aug 3 [cited 2021 Aug 3];36(5). Available from: http://www.cell.com/article/S2211124721009165/abstract
Steel RWJ, Vigdorovich V, Dambrauskas N, Wilder BK, Arredondo SA, Goswami D, Kumar S, Carbonetti S, Swearingen KE, Nguyen T, Betz W, Camargo N, Fisher BS, Soden J, Thomas H, Freeth J, Moritz RL, Sather DN*, Kappe SHI*. Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP. Sci Rep. 2021 May 31;11(1):11328. PMCID: PMC8166973
Harrington WE*, Trakhimets O, Andrade DV, Dambrauskas N, Raappana A, Jiang Y, Houck J, Selman W, Yang A, Vigdorovich V, Yeung W, Haglund M, Wallner J, Oldroyd A, Hardy S, Stewart SWA, Gervassi A, Van Voorhis W, Frenkel L, Sather DN*. Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19. Cell Rep Med 2021 Apr 20;2(4):100253. PMID33842901. PMC8020863.
Schafer C, Dambrauskas N, Reynolds LM, Trakhimets O, Raappana A, Flannery EL, Roobsoong W, Sattabongkot J, Mikolajczak SA, Kappe SHI* and Sather DN*. Partial protection against P. vivax infection diminishes hypnozoite burden and blood-stage relapses. Cell Host Microbe 2021 Apr 8. PMID33857426.
Yacoob C, Lange MD, Cohen K, Lathia K, Feng J, Glenn J, Carbonetti S, Oliver B, Vigdorovich V, Sather DN*, Stamatatos L*. B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques. PLoS Pathog 2018 Jun 22;14(6):e1007120. PMID: 29933399; PMCID: PMC6033445.