- Affiliate Assistant Professor, Global Health
- Affiliate Assistant Professor, Immunology
Institute for Systems Biology
401 Terry Ave N
Seattle, WA 98109
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Naeha Subramanian is an Assistant Professor at the Institute for Systems Biology and Affiliate Assistant Professor in the Department of Immunology, University of Washington. Her research focuses on the molecular mechanisms of innate immunity mediated by a class of cytosolic sensor proteins called NOD-like receptors (NLRs) that detect ligands of microbial or endogenous origin and stimulate innate immune activities. Gain of function mutations and polymorphisms in NLRs are associated with a host of severe human autoinflammatory and autoimmune disorders. The Subramanian lab aims to apply unbiased systems biology approaches to define NLR response phenotypes and associated signaling pathways. The goal is to provide insights into not only how NLRs normally function but to ultimately uncover new pathways to therapeutics for diseases related to aberrant NLR function. More information on Dr. Subramanian can be found here, and information on her lab can be found here.
- PhD (Jawaharlal Nehru University)
- MSc (University of Delhi)
- BSc (University of Delhi)
- Host-Pathogen Interactions
- Infectious Diseases
- Innate Immunity
- Molecular Immunology
- Systems Biology
Hampton H, Hutcheon C, Subramanian N. NAGging Hexokinase PEPs up NLRP3. Cell Host Microbe. Aug 10; 20(2):130-2, 2016.
Rommereim L.M., Subramanian, N. AIMing 2 Curtail Cancer. Cell. 162: 18-20, 2015.
Subramanian N*, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B*. Network representations of immune system complexity. Wiley Interdiscip Rev Syst Biol Med. Jan-Feb;7(1):13-38, 2015. *Corresponding authors
Subramanian, N*., Natarajan, K., Clatworthy, M., Wang, Z., Germain, R.N*. The adapter MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. 153: 348–361, 2013. *Corresponding authors.
Lee, G.S., Subramanian, N., Kim, A., Aksentijevich, I., Goldbach-Mansky, R., Sacks, D.B., Germain, R.N., Kastner, D.L., Chae, J.J. The calcium sensing receptor controls NLRP3 inflammasome activation through intracellular Ca2+ and cAMP. Nature 492: 123-127, 2012.