- Affiliate Professor, Global Health
- Affiliate Professor, Microbiology
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N
Seattle, WA 98109
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Dr. Emerman studies the replication of the human immunodeficiency virus, the virus that causes AIDS. His lab made key discoveries in how HIV infects cells including the ability of HIV to infect cells that are not actively dividing, the ability of HIV to transmit rapidly between cells, and the ability of HIV to encode genes that counter host defenses.
Along with his collaborator at the Fred Hutchinson Cancer Research Center, Dr. Harmit Malik, Dr. Emerman studies how humans and other primates have evolved to resist ancient viruses and how viruses have evolved to re-adapt to their hosts. This field, called Paleovirology, was established by Drs. Emerman and Malik as a means to explain how ancient and extinct viruses have had consequences for modern humans.
Dr. Emerman teaches a graduate course called "Human Pathogenic Viruses" that covers the replication, evolution, and pathogenesis of major human viral pathogens.
Dr. Emerman received his Ph.D from the University of Wisconsin-Madison in 1986 where he worked in the lab of Howard Temin, who shared the Nobel Prize for the discovery of reverse transcriptase, the key protein that allows viruses such as HIV to multiply their genomes.
Dr. Emerman was a postdoctoral fellow at the Pasteur Institute in Paris from 1986-1989 where is worked in the lab of Luc Montaganier who shared the Nobel Prize for the discovery of the virus that causes AIDS. He became a faculty member at the Fred Hutchinson in 1989. He has studied viruses for his entire scientific career.
For more information on the Emerman lab click here.
- BS (Ohio State University)
- PhD (University of Wisconsin)
HIV host-cell interactions
Etienne, L., Hahn, B.H., Sharp, P.M., Matsen, F.A., and Emerman, M. (2013) Gene loss and adaptation to hominids underlie the ancient origin of HIV-1. Cell Host Microbe, 14, 85-92.
Compton, A.A., Malik, H.S. and Emerman, M. (2013) Host Gene Evolution Traces the Evolutionary History of Ancient Primate Lentiviruses. Phil. Trans. of the Royal Society B, 12;368(1626).
Etienne, L., Bibollet-Ruche, F., Sudmant, P.H., Wu, Li.I., Hahn, B.H and Emerman, M. (2015) The role of the antiviral APOBEC3 gene family in protecting chimpanzees against lentiviruses from monkeys. PLOS Pathog, 11 (9): e1005149.
Wittkopp, C., Adolph, M.B. Wu, L.I., Chelico, and Emerman, M. (2016). A single nucleotide polymorphism in human APOBEC3C enhances restriction of lentiviruses PLOS Pathog, 12(10): e1005865.
Roesch, F., OhAinle, M. , and Emerman, M. A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology (2018) 15:26