• Affiliate Associate Professor, Global Health
  • Affiliate Associate Professor, Immunology
  • Assistant Member Fred Hutchinson Cancer Research Center
Martin Prlic

Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
1100 Eastlake Ave. E., E5-154
Seattle, WA 98109
United States

Phone Number: 
206-667-2216
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Biography 

The connecting theme throughout Dr. Prlic's research career has been my interest in lymphocyte differentiation. This started initially at the University of Salzburg, Austria, followed by his Ph.D. training at the University of Minnesota in the laboratory of Dr. Stephen Jameson. As a postdoctoral fellow at the University of Washington, he had the opportunity to establish his own T cell and NK cell research projects in the laboratory of Dr. Michael Bevan with a focus on T cell and NK cell responses in the context of infectious diseases. When Dr. Prlic started my own laboratory at the Fred Hutchinson Cancer Research Center in 2011, he continued his T cell work in the context of vaccination and infectious diseases. Through a close collaboration with Dr. Raphael Gottardo (FHCRC) his lab has started to examine human T cell subsets from blood and mucosal tissues using different single-cell gene expression analysis strategies. Our overall goal is to understand how T cell fate and function are controlled in healthy and inflamed tissues and following infection with HIV to identify how these responses can be manipulated for therapeutic purposes.

Education 
  • PhD (University of Minnesota)
  • MSc (University of Salzburg)
Languages 
  • German
Health Topics 
  • Cancer
  • Host-pathogen Interactions
  • Infectious Diseases
  • Molecular Immunology
Pathobiology research areas 
DGH Centers, Programs and Initiatives and Affiliated Organizations 
Publications 

Chu T, Tyznik AJ, Roepke S, Berkley AM, Woodward-Davis A, Pattacini L, Bevan MJ, Zehn D, Prlic M. Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep 3:701-708, 2013

Zehn D, Roepke S, Weakly K, Bevan MJ, Prlic M. Inflammation and TCR signal strength determine the breadth of the T cell response in a Bim-dependent manner. J Immunol 192:200-205, 2014

Slichter CK, Miller HW, McDavid A, Finak G, Seymour BJ, McNevin JP, Diaz G, Czartoski JL, McElrath MJ, Gottardo R and Prlic M. Distinct activation thresholds of human conventional and innate-like memory T-cells. J Clin Invest Insight. 2016;1(8):e86292.

Mpina M, Maurice NJ, Yajima M, Slichter CK, Miller HW, Dutta M, McElrath MJ, Stuart KD, De Rosa SC, McNevin JP, Linsley PS, Abdulla S, Tanner M, Hoffman SL, Gottardo R, Daubenberger CA, Prlic M. Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations. J Immunol. 2017 Jul 1;199(1):107-118

Reeves DB, Duke ER, Hughes SM, Prlic M, Hladik F, Schiffer JT. Anti-proliferative therapy for HIV cure: a compound interest approach. Sci Rep. 2017 Jun 21;7(1):4011