• Adjunct Associate Professor, Global Health
  • Associate Professor, Medicine - Allergy and Infectious Dis.

Harborview Medical Center
Research and Training Building
325 9th Ave Box 359779
Seattle, WA 98104
United States

Phone Number: 
206-897-5402
Email: 
giacal@uw.edu
Select from the following:
Biography 

Dr. Giacani officially joined the University of Washington in 2005 as a post-doctoral fellow in Sheila Lukehart`s lab with the purpose of continuing the research on Treponema pallidum virulence factors that he began in 2001 as graduate student at the University of Bologna and subsequently as a visiting scientist in Dr. Lukehart`s lab in 2002. In 2010 he became an Acting Instructor in the DOM-AID and in 2012 he transitioned to the rank of Assistant Professor after receiving external funding to support his research projects. Dr. Giacani is an Adjunct Assistant Professor in Global Health, and Faculty in the Pathobiology PhD program, where he fulfills his official teaching commitments.

Education 
  • PhD (University of Bologna (Italy))
  • BS (University of Bologna (Italy))
Country Affiliations 
Languages 
  • Italian
Health Topics 
  • Drug and Vaccine Development
  • Genomics
  • Infectious Diseases
  • Molecular Immunology
  • Neglected Diseases, Tropical Medicine (incl. Parasites)
  • Pathobiology
  • Pathogenesis
  • Research
  • STDs (other than HIV)
Expertise 

Pathogenesis of syphilis; congenital syphilis;gene regulation in Treponema pallidum, the agent of syphilis; treponema pallidum outer membrane proteins; subspecies and strains; vaccine development, antibiotic resistance; molecular epidemiology; multilocus strain typing system.

Publications 

Giacani L, Ciccarese G, Puga-Salazar C, Dal Conte I, Colli L, Cusini M, Ramoni S, Delmonte S, DʼAntuono A, Gaspari V, Drago F. Enhanced Molecular Typing of Treponema pallidum subspecies pallidum Strains From 4 Italian Hospitals Shows Geographical Differences in Strain Type Heterogeneity, Widespread Resistance to Macrolides, and Lack of Mutations Associated With Doxycycline Resistance. Sex Transm Dis. 2018 Apr;45(4):237-242. doi: 10.1097/OLQ.0000000000000741.
PMID:29465698

Godornes C, Giacani L, Barry AE, Mitja O, Lukehart SA. Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea. PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006113. doi: 10.1371/journal.pntd.0006113. eCollection 2017 Dec.
PMID:29281641

Arora N, Schuenemann VJ, Jäger G, Peltzer A, Seitz A, Herbig A, Strouhal M, Grillová L, Sánchez-Busó L, Kühnert D, Bos KI, Davis LR, Mikalová L, Bruisten S, Komericki P, French P, Grant PR, Pando MA, Vaulet LG, Fermepin MR, Martinez A, Centurion Lara A, Giacani L, Norris SJ, Šmajs D, Bosshard PP, González-Candelas F, Nieselt K, Krause J, Bagheri HC. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. Nat Microbiol. 2016 Dec 5;2:16245. doi:10.1038/nmicrobiol.2016.245.
PMID: 27918528

Chan K, Nasereddin T, Alter L, Centurion-Lara A, Giacani L, Parveen N. Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence. Sci Rep. 2016 May 10;6:25593. doi: 10.1038/srep25593. PMID:27161310

Giacani L, Brandt SL, Ke W, Reid TB, Molini BJ, Iverson-Cabral S, Ciccarese G, Drago F, Lukehart SA, Centurion-Lara A. Transcription of TP0126, Treponema pallidum putative OmpW homolog, is regulated by the length of a homopolymeric guanosine repeat. Infect Immun. 2015 Jun;83(6):2275-89. doi: 10.1128/IAI.00360-15. Epub 2015 Mar 23. PMID: 25802057