- Adjunct Professor, Global Health
- Professor, Pediatrics - Infectious Diseases
- Professor, Laboratory Medicine
- Adjunct Professor, Medicine - Allergy and Infectious Dis.
Pediatric Infectious Diseases Virology Clinic
4800 Sand Point Way NE
Seattle, WA 98105
Select from the following:
The Frenkel laboratory’s focuses on four primary areas of research:
First, we are working to understand the mechanisms that despite effective antiretroviral therapy that allow HIV infection to persist.
Second, our group conducts studies to elucidate how HIV infection, despite effective antiretroviral therapy, results in higher rates of cancers.
Third, we conduct “translational studies” in adults and children to understand the establishment and dynamics of HIV-drug-resistant reservoirs.
Fourth, in collaboration with bioengineers we are working to develop a rapid, affordable point mutation assay for detection of HIV-drug-resistance that should prove useful in both low- and high-resource communities.
A full listing of her journal publications can be found here.
- MD (University of Kansas Medical Center)
- BA (University of Kansas)
- Cervical Cancer
- HIV Transmission
- Host-pathogen Interactions
- Infectious Diseases
- Laboratory Strengthening
- Maternal Child Health (incl. Reproductive Health)
- STDs (other than HIV)
- A rapid point-of-treatment diagnostic assay for HIV-resistance to 1st-line ART
- Antiretroviral drug Resistance antenatally and during breastfeeding
- Defining Critical Events in Early HIV Infection: Effects of Alcohol & Early ART
- Defining HIV reservoirs that rebound following suspension of ART
- HIV integration-mediated modulation of immune regulation in HPV-associated cancers
- HIV-1 Evolution in the Female Genital Tract and Trafficking in the Blood
- International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group
- Mechanisms controlling the persistence of infectious HIV reservoirs in children
- Mechanisms of Formation and Persistence of Active HIV Reservoirs
- Targeted Long-acting Antiretroviral Therapy (TLC-ART)
Wagner TA, McLaughlin S, Garg K, Cheung CY, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. 2014. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345(6196):570-573. PMID25011556. PMCID: PMC4230336.
Chung MH, Beck IA, Dross S, Tapia K, Kiarie JN, Richardson BA, Overbaugh J, Sakr SR, John-Stewart GC, Frenkel LM. 2014. Oligonucleotide Ligation Assay Detects HIV Drug Resistance Associated With Virologic Failure Among Antiretroviral-Naive Adults in Kenya. J Acquir Immune Defic Syndr 67(3):246-253. PMID25140907. PMCID: PMC4197120.
Mullins JI and Frenkel LM. 2017. Clonal Expansion of Human Immunodeficiency Virus-Infected Cells and Human Immunodeficiency Virus Persistence During Antiretroviral Therapy. J Infect Dis 215(suppl_3):S119-S127. PMID28520966.
Duarte HA, Panpradist N, Beck IA, Lutz B, Lai J, Kanthula R, Kantor R, Tripathi A, Saravanan S, MacLeod I, Chung MH, Zhang G, Yang C, Frenkel LM. 2017. Current status of point-of-care testing for HIV drug resistance. J Infect Dis, in press. PMCID Journal – In Progress. (Invited peer-review.)