- Adjunct Professor, Global Health
- Professor, Pediatrics
- Professor, Laboratory Medicine
Pediatric Infectious Diseases Virology Clinic
4800 Sand Point Way NE
Seattle, WA 98105
Select from the following:
The Frenkel laboratory’s focuses on four primary areas of research:
First, we are working to understand the mechanisms that despite effective antiretroviral therapy that allow HIV infection to persist.
Second, our group conducts studies to elucidate how HIV infection, despite effective antiretroviral therapy, results in higher rates of cancers.
Third, we conduct “translational studies” in adults and children to understand the establishment and dynamics of HIV-drug-resistant reservoirs.
Fourth, in collaboration with bioengineers we are working to develop a rapid, affordable point mutation assay for detection of HIV-drug-resistance that should prove useful in both low- and high-resource communities.
A full listing of her journal publications can be found here
- MD (University of Kansas Medical Center)
- BA (University of Kansas)
- A rapid point-of-treatment diagnostic assay for HIV-resistance to 1st-line ART
- Defining Critical Events in Early HIV Infection: Effects of Alcohol and Early AR
- Drug-resistance testing in Kenya to improve ART suppression of HIV replication
- HIV integration-mediated modulation of immune regulation in HPV-associated cancer
- HIV-1 Evolution in the Female Genital Tract and Trafficking in the Blood
- International and Domestic Pediatric and Maternal HIV Studies Coordinating Center
- International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group
- Mechanisms of Formation and Persistence of Active HIV Reservoirs
- Targeted Long-acting Antiretroviral Therapy (TLC-ART)
Wagner TA, McLaughlin S, Garg K, Cheung CY, Larsen BB, Styrchak S, Huang HC, Edlefsen PT, Mullins JI, Frenkel LM. 2014. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345(6196):570-573. PMID25011556. PMCID: PMC4230336.
Mitchell C, Dross S, Beck I, Micek M, Frenkel LM. 2014. Low concentrations of HIV-1 DNA at birth delays diagnosis, complicating identification of infants for antiretroviral therapy to potentially prevent the establishment of viral reservoirs. Clin Infect Dis 58(8):1190-1193. PMID24501389. PMCID: PMC3967830.
Micek MA, Dross S, Blanco AJ, Beck IA, Matunha L, Seidel K, Montoya P, Matediana E, Gantt S, Gloyd S, Frenkel L. 2014. Transmission of nevirapine-resistant HIV Type 1 via breast milk to infants after single-dose nevirapine in Beira, Mozambique. J Infect Dis 210(4):641-645. PMID24596282. PMCID: PMC4133577.
Chung MH, Beck IA, Dross S, Tapia K, Kiarie JN, Richardson BA, Overbaugh J, Sakr SR, John-Stewart GC, Frenkel LM. 2014. Oligonucleotide Ligation Assay Detects HIV Drug Resistance Associated With Virologic Failure Among Antiretroviral-Naive Adults in Kenya. J Acquir Immune Defic Syndr 67(3):246-253. PMID25140907. PMCID: PMC4197120.
Ticona E, Bull ME, Soria J, Tapia K, Legard J, Styrchak SM, Williams C, Mitchell C, La Rosa A, Coombs RW, Frenkel LM. 2015. Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive anti-retroviral therapy (ART). AIDS 29(13):1617-1622. PMID26372272. PMCID: PMC4823992.
Chung MH, Silverman R, Beck IA, Yatich N, Dross S, McKernan-Mullin J, Bii S, Tapia K, Stern J, Chohan B, Sakr SR, Kiarie JN, Frenkel LM. 2016. Increasing HIV-1 pretreatment drug resistance among antiretroviral-naive adults initiating treatment between 2006 and 2014 in Nairobi, Kenya. AIDS 30(10):1680-1682. PMID27058353. PMCID: PMC4889515.
Goldman JD, Frenkel LM, Mullins JI. 2016. HIV Transmission During Condomless Sex with a Seropositive Partner with Suppressed Infection. JAMA (letter) 316(19):2044-2045. PMID27838715.
Mullins JI, Frenkel LM. 2017. Clonal expansion of HIV infected cells and HIV persistence during ART. J Infect Dis, in press.
Kanthula R, Rossouw T, Feucht UD, Van Dyk G, Beck IA, Silverman R, Olson S, Salyer C, Cassol S, Frenkel LM. 2017. Persistence of HIV-drug-resistance among South African Children given Nevirapine to Prevent Mother-to-Child-Transmission. AIDS, in press. PMCID Journal – In Progress (R01AI058723, P30AI027757, T32HD007233-32, U01AI068632)..