• Affiliate Professor, Global Health

1100 Fairview Ave. N
PO Box 19024
Seattle, WA 98195
United States

Phone Number: 
206-667-2995
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Biography 

Dr. Stamatatos’ s Lab investigates B cell responses to infection and vaccination. We are particularly interested in monitoring the activation, survival, and maturation of B cell clonal lineages that produce protective antibodies against infectious agents. New immunogens and immunization regiments are developed to target these B cell lineages and are tested in vivo. The Lab employs diverse experimental approaches, including structure-based immunogen-design, X-ray crystallography, next generation deep sequencing, and immunological, molecular, and cellular techniques. The Lab’s work encompasses the entire space between pre-clinical and clinical evaluation of candidate vaccines.

Education 
  • PhD (McGill University (Canada))
  • MS (University of Paris VI (France))
  • BS (University of Paris (France))
Country Affiliations 
Languages 
  • French
  • Greek
Health Topics 
  • HIV/AIDS
  • Immunizations
  • Infectious Diseases
Pathobiology research areas 
Publications 

Dosenovic. P, E. E. Kara, A.-K. Pettersson, A. McGuire, M. Gray, H. Hartweger, E. S. Thientosapol, L. Stamatatos and M C. Nussenzweig. 2018. Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinity. Proc. Natl. Acad. Sci. USA. 115(18); 4743-4748.

Yacoob, C., M. D. Lange, K. Cohen, K. Lathia, J. Feng, J. Glenn, S. Carbonetti, B. Oliver, V. Vigdorovich, D. N. Sather#, and L. Stamatatos#. 2018. B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques. PLoS Pathogens. 14(6): e1007120.

Escolano, A@., H. B. Gristick@, M. E. Abernathy, J. Merkenschlager, R. Gautam, T. Y. Oliveira, J. Pai, A. P. West, Jr., C. O. Barnes, A. A. Cohen, H. Wang, J. Golijanin, D. Yost, J. R. Keeffe, Z. Wang, P. Zhao, K-H. Yao, J. Bauer, L. Nogueira, H. Gao, A. V. Voll, D. C. Montefiori, M. S. Seaman, A. Gazumyan, M. Silva, A. T. McGuire, L. Stamatatos, D. J. Irvine, L. Wells, M. A. Martin, P. J. Bjorkman# and M. C. Nussenzweig#. 2019. Immunization expands HIV-1 glycan patch-specific B-cells in mice and macaques. In Press. Nature.

Dosenovic, P., A-K. Pettersson, A. Wall, E. Thientosapol, J. Feng, C. Weidle, K. Bhullar, E. Kara, H. Hartweger, J. Pai, M. Gray, K. R. Parks, J. Taylor, M. Pancera, L. Stamatatos#, M. Nussenzweig#, and A. T. McGuire#. 2019. Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses. In Press. The Journal of Experimental Medicine.

Bancroft, B., B. DeBuysscher, C. Weidle, A. Schwartz, A. Wall, M. D. Gray, J. Feng, H. R. Steach, K. Fitzpatrick, M. M. Gewe, P. D. Skog, C. Doyle-Cooper, T. Ota, R. K. Strong, D. Nemazee, M. Pancera, L. Stamatatos#, A. T. McGuire#, and J. Taylor#. 2019. Detection and in vivo activation of naive HIV-1 broadly neutralizing antibody precursor B cells using anti-idiotypes. In Press. The Journal of Experimental Medicine.