- Affiliate Professor, Global Health
1100 Fairview Ave. N
PO Box 19024
Seattle, WA 98195
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Dr. Stamatatos’ s Lab investigates B cell responses to infection and vaccination. We are particularly interested in monitoring the activation, survival, and maturation of B cell clonal lineages that produce protective antibodies against infectious agents. New immunogens and immunization regiments are developed to target these B cell lineages and are tested in vivo. The Lab employs diverse experimental approaches, including structure-based immunogen-design, X-ray crystallography, next generation deep sequencing, and immunological, molecular, and cellular techniques. The Lab’s work encompasses the entire space between pre-clinical and clinical evaluation of candidate vaccines.
- PhD (McGill University (Canada))
- MS (University of Paris VI (France))
- BS (University of Paris (France))
- Infectious Diseases
- CFAR: Immunology Core
- Consortia for HIV/AIDS Vaccine Development
- Defining BCR evolution during Immunization
- Eliciting VRC01-like bNAbs by Specifically Designed Env Immunogens
- Expansion and targeted maturation of germline HIV-1 bNAb-associated BCRs
- Immune Responses to Malaria and HIV Infection and Immunization
- Monitoring the development of anti-Env Abs during HIV-infection
- Neutralizing and non-neutralizing antibody effector functions in HIV infected children
Dosenovic. P, E. E. Kara, A.-K. Pettersson, A. McGuire, M. Gray, H. Hartweger, E. S. Thientosapol, L. Stamatatos and M C. Nussenzweig. 2018. Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinity. Proc. Natl. Acad. Sci. USA. 115(18); 4743-4748.
Yacoob, C., M. D. Lange, K. Cohen, K. Lathia, J. Feng, J. Glenn, S. Carbonetti, B. Oliver, V. Vigdorovich, D. N. Sather#, and L. Stamatatos#. 2018. B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of Rhesus macaques. PLoS Pathogens. 14(6): e1007120.
Escolano, A@., H. B. Gristick@, M. E. Abernathy, J. Merkenschlager, R. Gautam, T. Y. Oliveira, J. Pai, A. P. West, Jr., C. O. Barnes, A. A. Cohen, H. Wang, J. Golijanin, D. Yost, J. R. Keeffe, Z. Wang, P. Zhao, K-H. Yao, J. Bauer, L. Nogueira, H. Gao, A. V. Voll, D. C. Montefiori, M. S. Seaman, A. Gazumyan, M. Silva, A. T. McGuire, L. Stamatatos, D. J. Irvine, L. Wells, M. A. Martin, P. J. Bjorkman# and M. C. Nussenzweig#. 2019. Immunization expands HIV-1 glycan patch-specific B-cells in mice and macaques. In Press. Nature.
Dosenovic, P., A-K. Pettersson, A. Wall, E. Thientosapol, J. Feng, C. Weidle, K. Bhullar, E. Kara, H. Hartweger, J. Pai, M. Gray, K. R. Parks, J. Taylor, M. Pancera, L. Stamatatos#, M. Nussenzweig#, and A. T. McGuire#. 2019. Anti-idiotypic antibodies elicit anti-HIV-1-specific B cell responses. In Press. The Journal of Experimental Medicine.
Bancroft, B., B. DeBuysscher, C. Weidle, A. Schwartz, A. Wall, M. D. Gray, J. Feng, H. R. Steach, K. Fitzpatrick, M. M. Gewe, P. D. Skog, C. Doyle-Cooper, T. Ota, R. K. Strong, D. Nemazee, M. Pancera, L. Stamatatos#, A. T. McGuire#, and J. Taylor#. 2019. Detection and in vivo activation of naive HIV-1 broadly neutralizing antibody precursor B cells using anti-idiotypes. In Press. The Journal of Experimental Medicine.