- Adjunct Associate Professor, Global Health
- Associate Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Associate Professor, Microbiology
750 Republican St
UW Medicine Box 358061
Seattle, WA 98109
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The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion.
A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform.
- PhD (University of California (Berkeley))
- BS (University of California (Berkeley))
- Drug and Vaccine Development
- Host-Pathogen Interactions
- Infectious Diseases
- STDs (other than HIV)
Wang Y, LaBrie SD, Carrell SJ, Suchland RJ, Dimond ZE, Kwong F, Rockey DD, Hefty PS, Hybiske K. Development of Transposon Mutagenesis for Chlamydia muridarum. J Bacteriol. 2019 Nov 5;201(23):e00366-19. PMID:31501283.
Suchland RJ, Carrell SJ, Wang Y, Hybiske K, Kim DB, Dimond ZE, Hefty PS, Rockey DD. Chromosomal Recombination Targets in Chlamydia Interspecies Lateral Gene Transfer. J Bacteriol. 2019 Nov 5;201(23):e00365-19. PMID:31501285.
Dickinson MS, Anderson LN, Webb-Robertson BM, Hansen JR, Smith RD, Wright AT, Hybiske K. Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites. PLoS Pathog. 2019 Apr 3;15(4):e1007698. PMID:30943267.