• Affiliate Professor, Global Health
Ken Stuart

Center for Infectious Disease Research
307 Westlake Ave N., Suite 500
Seattle, WA 98109
United States

Phone Number: 
206-256-7200
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Biography 

Research in the Stuart Lab is focused on diseases that are caused by three related parasitic protozoa (Human African Trypanosomiasis [sleeping sickness], Chagas disease and Leishmaniasis) and on malaria, which is caused by another protozoan parasite. The lab investigates molecular and cellular processes of Trypanosomes and Leishmania, because this can lead to the development of drugs for these parasitic diseases. The lab is also is studying immune responses in clinical trials of malaria vaccines. For more details, see his profile.

Education 
  • PhD (University of Iowa)
  • MA (Wesleyan University)
  • BA (Northeastern University)
Country Affiliations 
Health Topics 
  • Drug and Vaccine Development
  • Infectious Diseases
  • Malaria
  • Pathobiology
Pathobiology research areas 
Expertise 

RNA Editing, Cell Systems; Antigenic Variation; Malaria Vaccine Development; Human African Trypanosomiasis (HAT); Chagas Disease; Leishmania

Publications 

Sekar, A., Merritt, C., Baugh, L., Stuart, K.D., Myler, P.J. (2014) Tb927.10.6900 encodes the glucosyltransferase involved in synthesis of base J in Trypanosoma brucei. Mol. Biochem. Parasitol. PMC4206709.

Carnes, J., Lerch, M., Kurtz, I., Stuart,K.D. (2015). Bloodstream form Trypanosoma brucei do not require mRPN1 for gRNA processing. RNA 21:28–35. PMC4274635.

Carnes, J., Anupama, A., Balmer, O., Jackson, A., Lewis, M., Brown, R., Cestari, I., Desquesnes, M., Gendrin, C., Hertz-Fowler C., Imamura, H., Ivens, A., Kořený, L., Lai, D.H., MacLeod, A., McDermott, S.M., Merritt, C., Monnerat, S., Moon, W., Myler P., Phan I., Ramasamy, G., Sivam, D., Lun, Z.R., Lukeš, J., Stuart, K.D., Schnaufer, A. (2015). Genome and Phylogenetic Analyses of Trypanosoma evansi Reveal Extensive Similarity to T. brucei and Multiple Independent Origins for Dyskinetoplasty. PLoS Negl Trop Dis. Jan 8;9(1):e3404. PMC4288722.

Phan I.Q., Davies D.R., Moretti N.S., Shanmugam D., Cestari I., Anupama A., Fairman J.W., Edwards T.E., Stuart, K.D., Schenkman S., Myler P.J. (2015). Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):615-21. PMID: 25961325.

Cestari, I., Stuart,K.D. (2015) Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes. 2015 May 11. pii: 201501206. PMID 25964327.