- Adjunct Associate Professor, Global Health
- Associate Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Associate Professor, Laboratory Medicine and Pathology
- Section Chief, Infectious Diseases, VA Puget Sound Health Care System
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The Shah lab is interested in understanding the factors that influence host immune responses to TB. In particular, we are focussed on ways that macrophages, the primary cell infected by M. tuberculosis, can maintain function during prolonged infection. To this end, the Shah Lab has identified the critical stress response gene, TOLLIP, as a TB susceptibility gene that influences macrophage function over time. Our lab is dedicated to pursuing how these genes and others like them influence TB pathogenesis using a combination of human population-based methods and small animal models.
Additionally, our lab has projects to study how pregnancy, a common states of immune modulation, influences host immune responses to M. tuberculosis antigen, with the goal of understanding the relative risks of TB during pregnancy, but also how certain immune changes during pregnancy can be compensated for until birth.
Dr. Shah is an affiliate member of the Center for Innate Immunity and Immune Disease (CIIID) and a member of the Core Leadership team of the Tuberculosis Research and Training Center.
- MD (University of Chicago)
- Host-Pathogen Interactions
- Infectious Diseases (other than STDs)
- Innate Immunity
- Molecular Immunology
TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia. Shah JA, Emery R, Lee B, Venkatasubramanian S, Simmons JD, Brown M, Hung CF, Prins JM, Verbon A, Hawn TR, Skerrett, SJ. Mucosal Immunol. 2019. In press.
A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin-Specific Immune Responses and Tuberculosis. Shah JA, Musvosvi M, Shey M, Horne DJ, Wells RD, Peterson GJ, Cox JS, Daya M, Hoal EG, Lin L, Gottardo R, Hanekom WA, Scriba TJ, Hatherill M, Hawn TR. Am J Respir Crit Care Med. 2017 Aug 15;196(4):502-511. doi: 10.1164/rccm.201611-2346OC.
Genetic Variation in Toll-Interacting Protein Is Associated With Leprosy Susceptibility and Cutaneous Expression of Interleukin 1 Receptor Antagonist. Shah JA, Berrington WR, Vary JC Jr, Wells RD, Peterson GJ, Kunwar CB, Khadge S, Hagge DA, Hawn TR. J Infect Dis. 2016 Apr 1;213(7):1189-97. doi: 10.1093/infdis/jiv570. Epub 2015 Nov 26.
Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, Dunstan SJ, Hawn TR. J Immunol. 2012 Aug 15;189(4):1737-46. doi: 10.4049/jimmunol.1103541. Epub 2012 Jul 9.
Dendritic cells are responsible for the capacity of CpG oligodeoxynucleotides to act as an adjuvant for protective vaccine immunity against Leishmania major in mice. Shah JA, Darrah PA, Ambrozak DR, Turon TN, Mendez S, Kirman J, Wu CY, Glaichenhaus N, Seder RA. J Exp Med. 2003 Jul 21;198(2):281-91.