- Associate Professor, Department of Microbiology
![Jason Smith PhD](https://globalhealth.washington.edu/sites/default/files/styles/faculty/public/faculty/Smith%2C%20Jason%2C%20PhD%20square.jpg?itok=jF-mQCHo)
UW Medicine South Lake Union
750 Republican St
Office: F-571
Seattle, WA 98109
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The Smith lab is primarily focused on understanding the role of defensins in viral pathogenesis and evolution. Defensins are a class of antimicrobial peptides with broad antibacterial, antiviral, and antifungal activity. Their effects on viral infection, immunity, pathogenesis, and evolution, particularly for nonenveloped viruses, are incompletely understood. Using a variety of approaches from virology, cell biology, biochemistry, structural biology, and genetics, our work is focused on understanding the interaction of defensins with non-enveloped viruses in molecular detail to determine general principals of defensin-mediated neutralization of viral infection. We are also interested in using animal models of enteric viral diseases to understand the role of defensins in antiviral immunity in vivo. Finally, we use 3D intestinal enteroid culture methodology to examine the interaction of viruses and bacteria with host cells and to study the cell biology of epithelial cell types that were previously unculturable.
- Newly recruited intraepithelial Ly6ACCR9CD4 T cells protect against enteric viral infection.Parsa R, London M, Rezende de Castro TB, Reis B, Buissant des Amorie J, Smith JG, Mucida DImmunity. 2022 07; 55 7: 1234-1249.e6
- VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection.Hu CT, Diaz K, Yang LC, Sharma A, Greenberg HB, Smith JGJournal of virology. 2022 04; 96 7: e0205321
- Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells.Bastounis EE, Serrano-Alcalde F, Radhakrishnan P, Engström P, Gómez-Benito MJ, Oswald MS, Yeh YT, Smith JG, Welch MD, García-Aznar JM, Theriot JADevelopmental cell. 2021 02; 56 4: 443-460.e11
- Defensin-driven viral evolution.Diaz K, Hu CT, Sul Y, Bromme BA, Myers ND, Skorohodova KV, Gounder AP, Smith JGPLoS pathogens. 2020 11; 16 11: e1009018
- Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes.Holly MK, Han X, Zhao EJ, Crowley SM, Allaire JM, Knodler LA, Vallance BA, Smith JGInfection and immunity. 2020 06; 88 7