- Professor, Global Health
- Professor, Microbiology
- Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Professor, Laboratory Medicine
University of Washington
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We use molecular, computational, and virus biology techniques to provide insights into the relationship between HIV and its human hosts in an effort to fight the AIDS pandemic. The practical benefits we derive from understanding both the dynamics of viral evolution and the host immune responses that occur during primary HIV infection and throughout the course of disease include an increasingly sophisticated understanding of the necessary features for a vaccine to provide protective immunity. Our current work in this area has been devoted to identifying components of each viral protein that should be included or excluded in a vaccine, the product of which is now in Phase I clinical trial. Our long-standing interest in the pathogenesis of HIV infection now centers on defining means of defining, reducing and eventually eliminating reservoirs of infection in HIV-infected humans. We are also developing software suite to capture, integrate and assist queries of databases from the patient bedside, to the laboratory, to the bioinformaticist's computers.
We also develop a series of stand-alone tools available free to the research community from our website.
A near complete listing of our laboratory’s publications can be found here
- PhD (University of Minnesota)
- BA (University of South Florida)
- Drug and Vaccine Development
- HIV Transmission
- Host-pathogen Interactions
- Infectious Diseases
- Infectious Diseases (other than STDs)
- Role of Proviral Loci in HIV Latency
- Biological Determinants of Natural History of AIDS-defining Cancers
- CFAR: Retrovirology and Molecular Data Science Core
- Conserved Elements Therapeutic DNA Vaccine for HIV
- Defining Critical Events in Early HIV Infection: Effects of Alcohol & Early ART
- Defining HIV reservoirs that rebound following suspension of ART
- Ex Vivo Detection and Analysis of Non-inducible Latent Reservoirs
- HIV integration-mediated modulation of immune regulation in HPV-associated cancers
- HIV Vaccine Trials Network (HVTN)
- Impact of Methamphetamine Use on the HIV Nucleome in individuals on Antiretroviral Therapy
- Martin Delaney Cure Collaboratory - Cell and Gene Therapy for HIV Cure
- Mechanisms of Formation and Persistence of Active HIV Reservoirs
- Modeling the Evolutionary and Public Health Impacts of HIV Adaptation in Response to Vaccination
Shankarappa, R., J. B. Margolick, S. J. Gange, A. G. Rodrigo, D. Upchurch, H. Farzadegan, P. Gupta, C. R. Rinaldo, G. H. Learn, X. He, X. L. Huang and J. I. Mullins (1999). "Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection." J. Virol. 73(12): 10489-10502.
Liu, Y., J. McNevin, J. Cao, H. Zhao, I. Genowati, K. Wong, S. McLaughlin, M. D. McSweyn, K. Diem, C. E. Stevens, J. Maenza, H. He, D. C. Nickle, D. Shriner, S. E. Holte, A. C. Collier, L. Corey, M. J. McElrath and J. I. Mullins (2006). "Selection on the human immunodeficiency virus type 1 proteome following primary infection." J Virol 80(19): 9519-9529.
Deeks, S. G., B. Autran, B. Berkhout, M. Benkirane, S. Cairns, N. Chomont, T. W. Chun, M. Churchill, M. Di Mascio, C. Katlama, A. Lafeuillade, A. Landay, M. Lederman, S. R. Lewin, F. Maldarelli, D. Margolis, M. Markowitz, J. Martinez-Picado, J. I. Mullins, J. Mellors, S. Moreno, U. O'Doherty, S. Palmer, M. C. Penicaud, M. Peterlin, G. Poli, J. P. Routy, C. Rouzioux, G. Silvestri, M. Stevenson, A. Telenti, C. Van Lint, E. Verdin, A. Woolfrey, J. Zaia and F. Barre-Sinoussi (2012). "Towards an HIV cure: a global scientific strategy." Nat Rev Immunol 12(8): 607-614.
Wagner, T. A., S. McLaughlin, K. Garg, C. Y. Cheung, B. B. Larsen, S. Styrchak, H. C. Huang, P. T. Edlefsen, J. I. Mullins and L. M. Frenkel (2014). "HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection." Science 345(6196): 570-573.
Hu, X., A. Valentin, F. Dayton, V. Kulkarni, C. Alicea, M. Rosati, B. Chowdhury, R. Gautam, K. E. Broderick, N. Y. Sardesai, M. A. Martin, J. I. Mullins, G. N. Pavlakis and B. K. Felber (2016). "DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV." J Immunol 197(10): 3999-4013.