- Professor, Global Health
- Professor, Medicine - Allergy and Infectious Dis.
- Adjunct Professor, Pediatrics
- Affiliate Investigator, Fred Hutchinson Cancer Research Center
International Clinical Research Center
908 Jefferson St.
Seattle, WA 98104
Select from the following:
Dr. Lingappa has been a faculty member at the University of Washington since 2004 and is currently a Professor in the Departments of Global Health and Medicine and Adjunct Professor in the Department of Pediatrics. He received his B.A. in Physics from Swarthmore College, Ph.D. in Biophysics at Harvard University and M.D. at the University of California. He completed residency training in Pediatrics and a fellowship in Pediatric Infectious Diseases at the University of Washington. From 1998 to 2003, he served as an officer with the US Public Health Epidemic Intelligence Service and subsequently as a medical epidemiologist at the U.S. Centers for Disease Control and Prevention in Atlanta, Georgia.
Since joining the UW faculty, he has collaborated with Drs. Connie Celum and Jared Baeten within the Department of Global Health International Clinical Research Center to conduct HIV-1 prevention clinical trials and observational studies in African heterosexual HIV-1 discordant couples. More recently, he has focused on conducting translational research studies to understand the pathogenesis of HIV-1 sexual transmission and particularly to identify host biological correlates for risk of HIV-1 infection. In this context he collaborates with numerous international researchers to apply genomics, proteomics and microbiome laboratory studies with state-of-the-art statistical analyses to identify factors that may be of particular relevance for public health interventions.
- MD (University of California (San Francisco))
- PhD (Harvard University)
- BA (Swarthmore College)
- Infectious Diseases
- Infectious Diseases (other than STDs)
1. Mackelprang R, Bamshad MJ, Chong JX, Hou X, Buckingham K, Shively K, deBruyn G, Mugo NR, Mullins JI, McElrath MJ, Baeten JM, Celum C, Emond MJ, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study and Partners PrEP Study Teams. Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1. PLoS Path. 2017;13:e1006703 PMCID: 5690691.
2. McClelland RS, Lingappa JR, Srinivasan S, Kinuthia J, John-Stewart GC, Jaoko W, Richardson BA, Yuhas K, Fiedler TL, Mandaliya KN, Munch MM, Mugo NR, Cohen CR, Baeten JM, Celum C, Overbaugh J, Fredricks DN. Evaluation of the association between the concentrations of key vaginal bacteria and the increased risk of HIV acquisition in African women from five cohorts: A nested case-control study. Lancet Infect Dis. 2018;18:554-64 PMCID: 6445552.
3. Mackelprang R, Scoville C, Cohen C, Ondondo R, Bigham A, Celum C, Campbell M, Essex M, Wald A, Kiarie J, Ronald A, Gray G, Lingappa JR. Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women. Genes Immun. 2015;16:362-5, PMCID: 4523061.
Lingappa JR, Petrovski S, Kahle E, Fellay J, Shianna K, McElrath MJ, Thomas KK, Baeten JM, Celum C, Wald A, de Bruyn G, Mullins JI, Nakku-Joloba E, Farquhar C, Essex M, Donnell D, Kiarie J, Haynes B, Goldstein D; Partners in Prevention HSV/HIV Transmission Study Team. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. PLoS One. 2011;6:e3236203. PMCID: 3236203.
Mackelprang RD, Baeten JM, Donnell D, Celum C, Farquhar C, de Bruyn G, Essex M, McElrath MJ, Nakku-Joloba E, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study Team. Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1. J Infect Dis. 2012;206:1299-1308. PMCID: 3448964.
Mackelprang RD, Carrington M, Thomas KK, Hughes J, Baeten JM, Wald A, Farquhar C, Fife K, Campbell MS, Kapiga S, Gao X, Mullins JI, Lingappa JR. Host genetic and viral determinants of HIV-1 RNA set point among HIV-1 seroconverters from sub-Saharan Africa. J Virol. 2015;89:2104-11. PMCID: 4338863.