- Adjunct Professor, Global Health
- Professor, Medicine - Allergy and Infectious Dis.
- Professor, Laboratory Medicine and Pathology
The Koelle Lab
750 Republican St., Room E651
Seattle, WA 98109
Select from the following:
Our lab works on the T cell immune response to a variety of human pathogens. Currently funded projects include Treponema pallidum (syphilis), herpes simplex virus types 1 and 2, varicella zoster virus (the cause of chicken pox and shingles), SARS-CoV-2, and Merkel cell polyoma virus (MCPyV, the cause of a viral skin cancer). We are fortunate to work with translational scientists including animal models and analysis of human specimens from vaccine clinical trials. David also does clinical work in Infectious Diseases at Harborview Medical Center,a component of UW Medicine.
- MD (University of Washington)
- BS (University of Washington)
- Biodefense Infectious Diseases
- Host-Pathogen Interactions
- Infectious Diseases (other than STDs)
- Molecular Immunology
- STDs (other than HIV)
Human and mouse immune responses to medically significant viral and protozoal pathogens, with an emphasis on T-cell responses.
- Immunodominant Viral Memory CD4 Epitopes of Biosecurity & Geriatric Medicine Concern
- Immunology of Merkel cell carcinoma
- Large Scale T cell epitope discovery
- Mechanisms of Severe T-cell Mediated Drug Hypersensitivity in Man
- T cell immune response to syphilis
- Tissue resident memory response to VZV infection
Boonyaratanakornkit J, Morishima C, Selke S, Zamora D, McCuffin S, Shapiro A, Campbell V, McClurkan CL, Jing L, Gross R, Liang J, Postnikova E, Mazur S, Lukin VV, Chaudhary A, Das MK, Fink S, Bryan A, Greninger A, Jerome KR, Holbrook M, Gernsheimer T, Wener M, Wald A, Koelle DM. 2021. Clinical, laboratory, and temporal predictors of neutralizing antibodies to SARS-CoV-2 after COVID-19 disease.131:e144930. Journal of Clinical Investigation. PMID 33320842. PMCID 7843229. [original work]
Jing L, Ott M, Church CD, Kulikauskas RM, Ibrani D, Iyer JG, Afanasiev OK, Colunga AG, Cook MM, Xie H, Greninger AL, Paulson KG, Chapuis AG, Bhatia S, Nghiem P, Koelle DM. 2020. High prevalence and diverse HLA restriction of intratumoral oncoprotein-specific CD8 T cells in polyoma virus-driven Merkel cell carcinoma. Cancer Immunology Research 8: 648-659. PMID 32179557. PMCID 7197523. [original work]
Elyanow R, Snyder TM, Dalai SC, Gittelman RM, Boonyaratanakornkit J, Wald A, Selke S, Wener MH, Morishima C, Greninger A, Holbrook MR, Kaplan IM, Carlson JM, Zahid HJ, Baldo L, Manley T, Robins H, Koelle DM. 2021. T-cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibody titers and disease severity. In Revision, Journal of Clinical Investigation. [original work] Preprint posted as https://www.medrxiv.org/content/10.1101/2021.03.19.21251426v1. PMID 33791723.
Koelle DM, Norberg P, Fitzgibbon MP, Russell RM, Greninger AL, Huang ML, Stensland L, Jing L, Magaret AS, Diem K, Selke S, Xie H, Celum C, Lingappa JR, Jerome KR, Wald A, Johnston C. 2017. Worldwide circulation of HSV-2 x HSV-1 recombinant strains. Scientific Reports 7: 44084. PMID 28287412. PMC ID PMC 5372922. [original work]
Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Kaja M-K, Koelle DM. 2015. Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome scanning. Tuberculosis 95:275-287 PMID 25857935. PMCID: PMC 4559191. [original work]