- Adjunct Professor, Global Health
- Professor, Medicine - Allergy and Infectious Dis.
- Professor, Laboratory Medicine and Pathology
The Koelle Lab
750 Republican St., Room E651
Seattle, WA 98109
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Dr. Koelle's lab uses the power of modern immunologic methods and molecular sequencing to understand the immune response to infectious pathogens. We want to create better vaccines and understand how existing vaccines work. Diseases of interest include herpes simplex and varicella zoster virus infections, syphilis, and virally induced cancers such as Kaposi's sarcoma and Merkel cell carcinoma. Within the UW Dept of Global Health, the lab is most closely associated with the Pathobiology program.
- MD (University of Washington)
- BS (University of Washington)
- Host-Pathogen Interactions
- Infectious Diseases
- Infectious Diseases (other than STDs)
- Innate Immunity
- STDs (other than HIV)
Human and mouse immune responses to medically significant viral and protozoal pathogens, with an emphasis on T-cell responses.
- Immunodominant Viral Memory CD4 Epitopes of Biosecurity & Geriatric Medicine Concern
- Immunology of Merkel cell carcinoma
- Large Scale T cell epitope discovery
- Mechanisms of Severe T-cell Mediated Drug Hypersensitivity in Man
- T cell immune response to syphilis
- Tissue resident memory response to VZV infection
Human CD4+ T cells specific for Merkel cell polyomavirus localize to Merkel cell carcinomas and target a required oncogenic domain. Longino NV, Yang J, Iyer JG, Ibrani D, Chow IT, Laing KJ, Campbell VL, Paulson KG, Kulikauskas RM, Church CD, James EA, Nghiem P, Kwok WW, Koelle DM.
Cancer Immunol Res. 2019 Aug 12. PMID: 31405946
Viral Genetics Modulate Orolabial Herpes Simplex Virus Type 1 Shedding in Humans. Ramchandani MS, Jing L, Russell RM, Tran T, Laing KJ, Magaret AS, Selke S, Cheng A, Huang ML, Xie H, Strachan E, Greninger AL, Roychoudhury P, Jerome KR, Wald A, Koelle DM. J Infect Dis. 2019 Mar 15;219(7):1058-1066. PMID: 30383234
Worldwide circulation of HSV-2 × HSV-1 recombinant strains. Koelle DM, Norberg P, Fitzgibbon MP, Russell RM, Greninger AL, Huang ML, Stensland L, Jing L, Magaret AS, Diem K, Selke S, Xie H, Celum C, Lingappa JR, Jerome KR, Wald A, Johnston C. Sci Rep. 2017 Mar 13 PMID: 28287142
Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract. Posavad CM, Zhao L, Dong L, Jin L, Stevens CE, Magaret AS, Johnston C, Wald A, Zhu J, Corey L, Koelle DM. Mucosal Immunol. 2017 Sep;10(5):1259-1269. PMID: 28051084
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG. Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229