- Affiliate Associate Professor, Global Health
Fred Hutchinson Cancer Research Center
1100 Fairview Ave N
C3-168
Seattle, WA 98109
United States
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Dr. Dara Lehman's interests include viral dynamics, viral reservoirs and viral transmission. In addition, she has been involved in the development of multiple assays to detect HIV infection and drug resistance that work across HIV subtypes, and uses these assays in population-based studies. Her current projects involve cohorts of HIV infected women and their infants in Kenya to study the reservoir of infected cells that persist despite suppressive treatment with antiretroviral therapy, as well as a study of mother to child transmission of the virome (population of all viruses). For more details on her current research projects see: https://research.fhcrc.org/overbaugh/en/lehman-lab.html
- PhD (University of Washington)
- MHS (Johns Hopkins University)
- BS (Tufts University)
- HIV Transmission
- HIV/AIDS
- Infectious Diseases
- Pathogenesis
- Viruses
Pankau MD, Reeves DB, Harkins E, Ronen K, Jaoko W, Mandaliya K, Graham SM, McClelland RS, Matsen Iv FA, Schiffer JT, Overbaugh J, Lehman DA. Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women. PLoS Pathog. 2020 Feb;16(2):e1008286. PMID: 32023326
Pankau MD, Wamalwa D, Benki-Nugent S, Tapia K, Ngugi E, Langat A, Otieno V, Moraa H, Maleche-Obimbo E, Overbaugh J, John-Stewart GC, Lehman DA. Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants. Open forum infectious diseases. 2018; 5(1):ofx268. PMID: 29354661
Weis JF, Baeten JM, McCoy CO, Warth C, Donnell D, Thomas KK, Hendrix CW, Marzinke MA, Mugo N, Matsen FA IV, Celum C, Lehman DA. Preexposure prophylaxis-selected drug resistance decays rapidly after drug cessation. AIDS (London, England). 2016; 30(1):31-5. NIHMSID: NIHMS728615 PMID:26731753
Lehman DA, Baeten JM, McCoy CO, Weis JF, Peterson D, Mbara G, Donnell D, Thomas KK, Hendrix CW, Marzinke MA, Frenkel L, Ndase P, Mugo NR, Celum C, Overbaugh J, Matsen FA, Partners PrEP Study Team. Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single- or dual-agent preexposure prophylaxis. 2015. J Infect Dis. 211(8): 1211-1218.
Boyle DS*, Lehman DA*, Lillis L, Peterson D, Singhal M, Armes N, Parker M, Piepenburg O, Overbaugh J. Rapid detection of HIV-1 proviral DNA for early infant diagnosis using recombinase polymerase amplification. 2013. MBio 4(2). pii: e00135-13. *co-first author