• Adjunct Associate Professor, Global Health
Christoph Grundner

Seattle, WA
United States

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Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to find new and better therapies. The Grundner lab seeks to map the signaling pathways that underlie Mtb’s adaptability and pathogenesis. These studies provide fundamental insight into Mtb biology and identify new targets for therapeutic interference. A major bottleneck in Mtb research on every level is the large number of genes with unknown function in the Mtb genome. We use chemical proteomics approaches towards high-throughput identification of functions for these unknown proteins. These new tools allow probing of even the most divergent enzyme space.

  • PhD (University of Heidelberg (Germany))
  • MS (Humboldt University (Germany))
  • BS (University of Bonn (Germany))
Country Affiliations 
  • German
Health Topics 
  • Drug and Vaccine Development
  • Infectious Diseases (other than STDs)
  • TB
Pathobiology research areas 

Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck ND, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith D, Kappe S, Wright A, Grundner C. A global survey of ATPase activity in Plasmodium falciparum asexual blood stages and gametocytes. Mol Cell Proteomics. 2018 Oct 27. PMID: 29079720

Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C. Changes in serine hydrolase activity associated with Mycobacterium tuberculosis replication. Cell Chem Biol. 2016 Feb 18;23(2):290-8. PMID: 26853625

Sherman DR, Grundner C. Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling. Mol Microbiol. 2014 Oct;94(2):231-41. PMID: 25099260

Kusebauch U, Ortega C, Ollodart A, Rogers R, Sherman DR, Moritz R, Grundner C. Mycobacterium tuberculosis supports protein tyrosine phosphorylation. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70. PMID: 24927537

Ortega C, Liao R, Anderson L, Rustad T, Ollodart A, Wright A, Sherman DR, Grundner C. Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. PLoS Biology, 2014 Jan;12(1):e1001746. PMID: 24409094