Over the past 15 years, Benson Singa has been a clinical research scientist at the Kenya Medical Research Institute (KEMRI), Center for Clinical Research (CCR), where he has been a close collaborator on several studies of helminth, malaria, STI and HIV co-infection over the past years including programmatic evaluation. He has served as a principal investigator, a co-investigator, and a medical coordinator on these studies. Benson's background interest is in Public Health especially Sexual, Reproductive, Adolescent and Child Health. These interests encompass preventive, promotive, and curative services. He has additional interests in tropical medicine especially immune modulation and interaction between tropical diseases and HIV, including current emerging issues and progress in this field given the continuing concern of barely contained tropical diseases and HIV infection around the globe.

Currently, Benson is involved in evaluating ongoing programs especially PMTCT program and HIV in children and adolescents in a bid to improve the preventive programs being implemented in the healthcare set up. This has been done in collaboration with NASCOP-Kenya, CDC (Kenya & Atlanta), University of Washington and the Christian Health Association, Kenya (CHAK). The results of these evaluations have been used by the Kenya Ministry of Health to improve services. Additionally, Benson has been involved in multi-country, multi-site Clinical Trials and observational research studies around Diarrhoea and Childhood Acute Illness and Nutrition. One of the common elements in all these studies is the role of malnutrition in the cause or exacerbation of ill health in children under the age of 5 years. Given the role microbiome may play in contributing to either the development, progress and treatment and recovery in childhood acute illness, a better understanding of the relationship between the various microbiome environments and disease severity and outcomes to better identify children at high risk of poor outcomes, in order to employ targeted therapeutics, and reduce attributable childhood mortality is a major interest.