• Principal Investigator, Supervisor, Center for Global Infectious Disease Research
  • Adjunct Assistant Professor, Global Health
  • Assistant Professor, Pediatrics - Infectious Diseases

Seattle Children's Research Institute
307 Westlake Ave N
Seattle, WA 98109-5219

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Ashley Vaughan, PhD, is a research assistant professor. He received his PhD from the London School of Hygiene and Tropical Medicine. During his tenure in the Kappe Lab, he showed the importance of the parasite’s fatty acid synthetic pathway for sporozoite and liver stage maturation. He also researches how to elicit the most protective immune response after vaccination with genetically attenuated parasites. Ashley’s collaborations with Sebastian Mikolajczak led to significant advances in the use of human-liver chimeric mouse models in studying malaria. This includes complete liver stage development and the transition to blood stage malaria in the mouse for the human malarias Plasmodium falciparum and Plasmodium vivax. He has also used this mouse model for the creation of experimental Plasmodium falciparum genetic crosses, a significant advance that should aid in our understanding of Plasmodium falciparum drug resistance. Ashley continues to be fascinated by basic parasite pre-erythrocytic biology and uses rodent malaria and parasite transgenesis to understand how the parasite interacts with its vector and host during sporozoite and liver stage development. Outside of the lab, he is a keen hiker, traveler, gardener and scuba diver, pastimes he enjoys with and without his husband, Rafael.

  • PhD, London School of Hygiene and Tropical Medicine (UK)
  • BSc, University of Bath (UK)
Health Topics 
  • Biotechnology
  • Drug Resistance
  • Genetic Engineering
  • Genetics
  • Host-Pathogen Interactions
  • Immunology
  • Infectious Diseases
  • Malaria
  • Systems Biology

Goswami D, Betz W, Locham NK, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Kennedy SY, Murphy SC, Vaughan AM, Kappe SH. A Replication-Competent Late Liver Stage-Attenuated Human Malaria Parasite. JCI Insight, 2020 Jun 2 : Epub ahead135589 https://pubmed.ncbi.nlm.nih.gov/32484795/

Zhou Y, Grieser AM, Do J, Itsara LS, Vaughan AM, Ghosh AK. Purification and Production of Plasmodium falciparum Zygotes From in Vitro Culture Using Magnetic Column and Percoll Density Gradient. Malar. J., 2020 May 25 : 19(1)192 PMCID:PMC7249376 https://pubmed.ncbi.nlm.nih.gov/32450861/

Li X, Kumar S, McDew-White M, Haile M, Cheeseman IH, Emrich S, Button-Simons K, Nosten F, Kappe SHI, Ferdig MT, Anderson TJC, Vaughan AM. Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle. PLoS Genet., 2019 Oct 14 : 15(10)e1008453. PMCID:PMC6821138 https://www.ncbi.nlm.nih.gov/pubmed/31609965

Minkah NK, Wilder BK, Sheikh AA, Martinson T, Wegmair L, Vaughan AM, Kappe SHI. Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites. Nat Commun., 2019 Sep 2 : 10(1)3950 PMCID:PMC6718385 https://www.ncbi.nlm.nih.gov/pubmed/31477704

Tirrell AR, Vendrely KM, Checkley LA, Davis SZ, McDew-White M, Cheeseman IH, Vaughan AM, Nosten FH, Anderson TJC, Ferdig MT. Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates. Malar J., 2019 Aug 28 : 18(1)295 PMCID:PMC6714446 https://www.ncbi.nlm.nih.gov/pubmed/31462253


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