- Associate Professor, UW Immunology
- Adjunct Associate Professor, Laboratory Medicine and Pathology
Seattle Children's Research Institute
JMB-7 - Immunology
1900 9th Ave Seattle, WA 98101
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Adrian Piliponsky, PhD, is a principal investigator within the Center for Immunity and Immunotherapeutics at Seattle Childrens Research Institute, and an assistant professor in the Department of Pediatrics at the University of Washington School of Medicine.
Dr. Piliponsky received his bachelors degree in Pharmacy from the University of Buenos Aires in Argentina. His passion for research eventually led him to The Hebrew University of Jerusalem in Israel where Dr. Piliponsky received his PhD. Under the mentorship of Francesca Levi-Schaffer, PhD, Dr. Piliponsky studied interactions of mast cells and eosinophils which are considered major players of allergies. With a desire to broaden his understanding of mast cells in vivousing mice with deficiencies in mast cells to study a variety of allergy and inflammatory disordersDr. Piliponsky took a post-doctoral position at Stanford University with Stephen J. Galli, MD, one of the lead researchers in the mast cell field.
Schäfer B, Piliponsky AM, Oka T, Song CH, Gerard NP, Gerard C, Tsai M, Kalesnikoff J, Galli SJ,
"Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice."
The Journal of allergy and clinical immunology 131.2 (2013 Feb): 541-8.e1-9.
Piliponsky AM, Chen CC, Rios EJ, Treuting PM, Lahiri A, Abrink M, Pejler G, Tsai M, Galli SJ,
"The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis."
The American journal of pathology 181.3 (2012 Sep): 875-86.
Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS,
"Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33."
The Journal of allergy and clinical immunology 133.5 (2014 May): 1448-55.
Gendrin C, Vornhagen J, Ngo L, Whidbey C, Boldenow E, Santana-Ufret V, Clauson M, Burnside K, Galloway DP, Adams Waldorf KM, Piliponsky AM, Rajagopal L,
"Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection."
Science advances 1.6 (2015 Jul 17): e1400225.
Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF,
"Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis."
American journal of respiratory cell and molecular biology 55.2 (2016 Aug): 264-74.
Shubin NJ, Glukhova VA, Clauson M, Truong P, Abrink M, Pejler G, White NJ, Deutsch GH, Reeves SR, Vaisar T, James RG, Piliponsky AM,
"Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation."
The Journal of allergy and clinical immunology 139.1 (2017 Jan): 323-334.
Gendrin C, Shubin NJ, Boldenow E, Merillat S, Clauson M, Power D, Doran KS, Abrink M, Pejler G, Rajagopal L, Piliponsky AM,
"Mast cell chymase decreases the severity of group B Streptococcus infections."
The Journal of allergy and clinical immunology 142.1 (2018 Jul): 120-129.e6.
Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS,
"Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen."
JCI insight 2.21 (2017 Nov 2): .
Piliponsky AM, Romani L,
"The contribution of mast cells to bacterial and fungal infection immunity."
Immunological reviews 282.1 (2018 Mar): 188-197.
Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ,
"Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice."
Nature immunology 20.2 (2019 Feb): 129-140.
Piliponsky AM, Acharya M, Shubin NJ,
"Mast Cells in Viral, Bacterial, and Fungal Infection Immunity."
International journal of molecular sciences 20.12 (2019 Jun 12): .
Altman MC, Lai Y, Nolin JD, Long S, Chen CC, Piliponsky AM, Altemeier WA, Larmore M, Frevert CW, Mulligan MS, Ziegler SF, Debley JS, Peters MC, Hallstrand TS,
"Airway epithelium-shifted mast cell infiltration regulates asthmatic inflammation via IL-33 signaling."
The Journal of clinical investigation 129.11 (2019 Nov 1): 4979-4991.
Shubin NJ, Navalkar K, Sampson D, Yager TD, Cermelli S, Seldon T, Sullivan E, Zimmerman JJ, Permut LC, Piliponsky AM,
"Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach."
Critical care medicine 48.1 (2020 Jan): e48-e57.
Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS,
"Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases."
Frontiers in immunology 10. (2019): 3159.
Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM,
"Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition."
Mucosal immunology . (2020 Feb 26): .