Discover our impact all over the world.

Numbers displayed on the map are a representation of the activity in each country. Once you use the filter selections below, you will have the opportunity to explore projects and faculty in each country.

Projects + Faculty = Activity Number

##

Overview

Projects 304
Countries 145
Faculty 380
Health Topics 123

Filter from the selections below

Clear All Filters

The HIV-1 capsid assembly pathway: cellular factors and links to pathogenesis

The Lingappa lab studies viral host interactions involved in assembly of human immunodeficiency virus type 1 (HIV-1) and other viruses.  Previously, our group demonstrated that immature HIV-1 capsid assembly in cells occurs through a pathway of assembly intermediates, and is facilitated by the catalytic activity of the host enzymes ABCE1 and DDX6.  Our recent studies show that ABCE1 binds directly to HIV Gag through an ancient binding site that is present even in the Ty3 retrotransposon Gag protein.  One current project in the lab involves understanding the evolution of the ABCE1 binding site in different retroviral Gag proteins.  A second project in the lab involves studying how HIV-1 genomic RNA is packaged into the assembling virus in cells.  A third project address how polymorphisms that arise in Gag in vivo can enhance ABCE1-Gag binding, thereby accelerating the kinetics of assembly and increasing virus particle production.  The latter studies have important implications for viral pathogenesis, since they test the hypothesis that altering viral-host interactions during assembly could impact viral set point and viral load.  The Lingappa lab’s studies have also led to development of novel antiretroviral compounds that inhibit virus replication by acting on the capsid assembly pathway.

Countries 
Active Dates 
01/01/2002 to 12/31/2018
Faculty Involved 
Health Topics