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Multiplexible Autonomous Disposable Nucleic Acid Amplification Test for Chlamydia and Gonorrhea: Addressing an Epidemic Threat to Readiness at the Point-of-Care

Chlamydia trachomatis (CT) is a prevalent infection resulting in pelvic inflammatory disease, ectopic pregnancy, infertility and acute and chronic pelvic pain. In the military, CT is a leading cause of reduced readiness among service women, with age- and race-adjusted infection rates nearly six times higher than civilian rates. Current diagnostic tests for CT require up to 48 hours to process, and risk missed treatment due to lack of follow up. Though point of care testing is urgently needed to address this gap, attempts to date have suffered from test inaccuracy. Recently, we developed the Multiplexable Autonomous Disposable Nucleic Acid Amplification Test (MAD NAAT) for the diagnosis of CT and Neisseria gonorrhoeae (NG) with 100% sensitivity and specificity in pre-clinical testing. The aim of the study is to demonstrate the value of the refined (smaller, faster) MD NAAT technology platform for point-of-care clinical testing of urine from collection to detecdtion in less than 1 hour.

Active Dates 
09/01/2018 to 03/30/2020
Faculty Involved