• Adjunct Professor, Global Health
  • Associate Chair, Medicine
  • Professor, Medicine - Allergy and Infectious Dis.
  • Adjunct Professor, Pathology
  • Adjunct Professor, Pharmacology

1959 NE Pacific St.
HSB RR-511
Seattle, WA 98195
United States

Phone Number: 
206-221-6965
Email: 
wcliles@uw.edu
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Biography 

Dr. Liles returned to the University of Washington in 2012 from the University of Toronto, where he was Vice-Chair and Professor of Medicine, Director of the Division of Infectious Diseases, and the Canada Research Chair in Infectious Diseases and Inflammation. In addition to his duties as Professor and Associate Chair, Dr. Liles serves as Co-Director of the Molecular Medicine Training Program at the University of Washington. The overall mission of his research program is to investigate clinical problems at the bench, in order to gain novel insights into disease pathogenesis and to develop novel therapeutic approaches to important clinical problems. His laboratory focuses on the role of dysregulated host responses in the pathogenesis of infectious diseases of public health importance. A guiding principle of his research program is rapid translation of experimental insights and advances gained in the laboratory to the clinical bedside. Areas of current research include: the molecular immunopathogenesis of malaria, sepsis, hemolytic-uremic syndrome (HUS), severe influenza, acute respiratory distress syndrom (ARDS), multiple organ dysfunction syndrome (MODS), and the role and regulation of endothelial activation/dysfunction in life-threatening infectious diseases.
 
The role of innate immunity and inflammation in the development of effective acquired/adaptive immunity to infectious diseases is an emerging interest in his laboratory, as is prognostic host-derived biomarker discovery. His research utilizes a variety of molecular and cellular biology technologies (e.g., transfection/transduction strategies, real-time PCR, siRNA technology, Western blot, ELISA, etc.), expression microarray technology, mesenchymal stem cell and adoptive cell transfer technology, cell culture, work with patient specimens, and clinically relevant mouse models of malaria, sepsis, and acute lung injury. His research laboratory is located in the SLU 3.1 facility, where he is a member of CERID.


Education 
  • PhD (University of Washington)
  • MD (University of Washington)
  • BA (Williams College)
Country Affiliations 
Languages 
  • French
Health Topics 
  • Infectious Diseases
  • Infectious Diseases (other than STDs)
  • Malaria
  • Molecular Immunology
  • Mortality
  • Pathogenesis
DGH Centers, Programs and Initiatives and Affiliated Organizations 
Publications 

Skinner JF, Calkins HH, Liles WC, Kaplan LJ. Spin-label studies of the pH-induced random coil to alpha-helix conformational transition in poly-L-lysine. Biopolymers 1982; 21:833-847.

Liles WC, Nathanson NM. Regulation of neuronal muscarinic acetylcholine receptor number by protein glycosylation. J Neurochem 1986; 46:89-95.  PMID:  3940294

Liles WC, Taylor S, Finnell R, Lai H, Nathanson NM. Decreased muscarinic acetylcholine receptor number in the central nervous system of the tottering (tg/tg) mouse. J Neurochem 1986; 46:977-982.  PMID:  3950615

Liles WC, Hunter DD, Meier KE, Nathanson NM. Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells. J Biol Chem 1986; 261:5307-5313.  PMID:  3082882

Liles WC, Nathanson NM. Regulation of muscarinic acetylcholine receptor number in cultured neuronal cells by chronic membrane depolarization. J Neurosci 1987; 7:2556-2563.  PMID:  3039081