• Affiliate Assistant Professor, Global Health

1100 Fairview Ave N
Mailstop E5-155
Seattle, WA 98109
United States

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Dr. Leslie Goo studies the immune response to flaviviruses, which are transmitted to humans by mosquitoes and ticks and are significant threats to public health around the globe. They include dengue virus, West Nile virus, Zika virus, Japanese encephalitis virus and yellow fever virus. To understand the mechanisms behind immunity and disease development, she explores how immune proteins known as antibodies interact with viral and cellular factors. Her research addresses both fundamental and translational questions, including those relevant to the development of vaccines and antiviral drugs.

Country Affiliations 
  • Indonesian
  • Mandarin
Health Topics 
  • Host-Pathogen Interactions
  • Infectious Diseases (other than STDs)
  • Neglected Diseases, Tropical Medicine (incl. Parasites)
  • Pathobiology
  • Pathogenesis
  • Trop. Med (incl. Parasites)
  • Viruses
  • Zoonotic Diseases and Animal Health
DGH Centers, Programs and Initiatives and Affiliated Organizations 

Durham ND, Agrawal A, Waltari E, Croote D, Zanini F, Fouch M, Davidson E, Smith O, Carabajal E, Pak JE, Doranz BJ, Robinson M, Sanz AM, Albornoz LL, Rosso F, Einav S, Quake SR, McCutcheon KM, Goo L."Broadly Neutralizing Human Antibodies Against Dengue Virus Identified by Single B Cell Transcriptomics." Elife. 2019 Dec 10;8:e52384. doi: 10.7554/eLife.52384. PMID: 31820734 PMCID: PMC6927745

Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE Jr, Pierson TC. "A Protective Human Monoclonal Antibody Targeting the West Nile Virus E Protein Preferentially Recognizes Mature Virions." Nat Microbiol. 2019 Jan;4(1):71-77. doi: 10.1038/s41564-018-0283-7. PMID: 30455471 PMCID: PMC6435290

Goo L, DeMaso CR, Pelc RS, Ledgerwood JE, Graham BS, Kuhn RJ, Pierson TC. "The Zika Virus Envelope Protein Glycan Loop Regulates Virion Antigenicity." Virology. 2018 Feb;515:191-202. doi: 10.1016/j.virol.2017.12.032. PMID: 29304471

Goo L, VanBlargan LA, Dowd KA, Diamond MS, Pierson TC. "A Single Mutation in the Envelope Protein Modulates Flavivirus Antigenicity, Stability, and Pathogenesis." PLoS Pathog. 2017 Feb 16;13(2):e1006178. doi: 10.1371/journal.ppat.1006178. PMID: 28207910 PMCID: PMC5312798

Goo L, Chohan V, Nduati R, Overbaugh J. "Early Development of Broadly Neutralizing Antibodies in HIV-1-infected Infants." Nat Med. 2014 Jun;20(6):655-8. doi: 10.1038/nm.3565. PMID: 24859529 PMCID: PMC4060046